Delivery and targeting of oligonucleotides and siRNA

Ningning Yang, Ram I. Mahato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Oligodeoxynucleotides (ODNs) are increasingly being recognized as potential therapeutic agents to modulate aberrant gene expression for treating various diseases, including cancers1-3 and viral infections.4,5 Concerted efforts have made signicant progress in turning these nucleic acids into therapeutics. Apart from immune-stimulation and enzymatic cleavage, the most important feature of ODNs is their ability to block mRNA function by sequence-specic hybridization with target mRNA.6 Theoretically, the antisense strategy can be used to target any gene in the body, which allows these nucleic acids to achieve broader therapeutic potential than small molecules.

Original languageEnglish (US)
Title of host publicationTargeted Delivery of Small and Macromolecular Drugs
PublisherCRC Press
Pages147-170
Number of pages24
ISBN (Electronic)9781420087734
ISBN (Print)9781420087727
DOIs
StatePublished - Jan 1 2010

Fingerprint

Oligonucleotides
Small Interfering RNA
Oligodeoxyribonucleotides
Nucleic Acids
Therapeutics
Gene Expression
Messenger RNA
Genes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Yang, N., & Mahato, R. I. (2010). Delivery and targeting of oligonucleotides and siRNA. In Targeted Delivery of Small and Macromolecular Drugs (pp. 147-170). CRC Press. https://doi.org/10.1201/9781420087734

Delivery and targeting of oligonucleotides and siRNA. / Yang, Ningning; Mahato, Ram I.

Targeted Delivery of Small and Macromolecular Drugs. CRC Press, 2010. p. 147-170.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yang, N & Mahato, RI 2010, Delivery and targeting of oligonucleotides and siRNA. in Targeted Delivery of Small and Macromolecular Drugs. CRC Press, pp. 147-170. https://doi.org/10.1201/9781420087734
Yang N, Mahato RI. Delivery and targeting of oligonucleotides and siRNA. In Targeted Delivery of Small and Macromolecular Drugs. CRC Press. 2010. p. 147-170 https://doi.org/10.1201/9781420087734
Yang, Ningning ; Mahato, Ram I. / Delivery and targeting of oligonucleotides and siRNA. Targeted Delivery of Small and Macromolecular Drugs. CRC Press, 2010. pp. 147-170
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