Delirium in Critically Ill Children

An International Point Prevalence Study∗

Chani Traube, Gabrielle Silver, Ron W. Reeder, Hannah Doyle, Emily Hegel, Heather A. Wolfe, Christopher Schneller, Melissa G. Chung, Leslie A. Dervan, Jane L. Digennaro, Sandra D.W. Buttram, Sapna R. Kudchadkar, Kate Madden, Mary E. Hartman, Mary L. Dealmeida, Karen Walson, Erwin Ista, Manuel A. Baarslag, Rosanne Salonia, John Beca & 12 others Debbie Long, Yu Kawai, Ira M. Cheifetz, Javier Gelvez, Edward J Truemper, Rebecca L. Smith, Megan E. Peters, Am Iqbal O'Meara, Sarah Murphy, Abdulmohsen Bokhary, Bruce M. Greenwald, Michael J. Bell

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objectives: To determine prevalence of delirium in critically ill children and explore associated risk factors. Design: Multi-institutional point prevalence study. Setting: Twenty-five pediatric critical care units in the United States, the Netherlands, New Zealand, Australia, and Saudi Arabia. Patients: All children admitted to the pediatric critical care units on designated study days (n = 994). Intervention: Children were screened for delirium using the Cornell Assessment of Pediatric Delirium by the bedside nurse. Demographic and treatment-related variables were collected. Measurements and Main Results: Primary study outcome measure was prevalence of delirium. In 159 children, a final determination of mental status could not be ascertained. Of the 835 remaining subjects, 25% screened positive for delirium, 13% were classified as comatose, and 62% were delirium-free and coma-free. Delirium prevalence rates varied significantly with reason for ICU admission, with highest delirium rates found in children admitted with an infectious or inflammatory disorder. For children who were in the PICU for 6 or more days, delirium prevalence rate was 38%. In a multivariate model, risk factors independently associated with development of delirium included age less than 2 years, mechanical ventilation, benzodiazepines, narcotics, use of physical restraints, and exposure to vasopressors and antiepileptics. Conclusions: Delirium is a prevalent complication of critical illness in children, with identifiable risk factors. Further multi-institutional, longitudinal studies are required to investigate effect of delirium on long-term outcomes and possible preventive and treatment measures. Universal delirium screening is practical and can be implemented in pediatric critical care units.

Original languageEnglish (US)
Pages (from-to)584-590
Number of pages7
JournalCritical care medicine
Volume45
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Delirium
Critical Illness
Cross-Sectional Studies
Critical Care
Pediatrics
Coma
Physical Restraint
Saudi Arabia
Narcotics
Benzodiazepines
New Zealand
Artificial Respiration
Netherlands
Anticonvulsants
Longitudinal Studies

Keywords

  • critical care
  • delirium
  • neurocritical care
  • pediatric
  • prevalence

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Traube, C., Silver, G., Reeder, R. W., Doyle, H., Hegel, E., Wolfe, H. A., ... Bell, M. J. (2017). Delirium in Critically Ill Children: An International Point Prevalence Study∗. Critical care medicine, 45(4), 584-590. https://doi.org/10.1097/CCM.0000000000002250

Delirium in Critically Ill Children : An International Point Prevalence Study∗. / Traube, Chani; Silver, Gabrielle; Reeder, Ron W.; Doyle, Hannah; Hegel, Emily; Wolfe, Heather A.; Schneller, Christopher; Chung, Melissa G.; Dervan, Leslie A.; Digennaro, Jane L.; Buttram, Sandra D.W.; Kudchadkar, Sapna R.; Madden, Kate; Hartman, Mary E.; Dealmeida, Mary L.; Walson, Karen; Ista, Erwin; Baarslag, Manuel A.; Salonia, Rosanne; Beca, John; Long, Debbie; Kawai, Yu; Cheifetz, Ira M.; Gelvez, Javier; Truemper, Edward J; Smith, Rebecca L.; Peters, Megan E.; O'Meara, Am Iqbal; Murphy, Sarah; Bokhary, Abdulmohsen; Greenwald, Bruce M.; Bell, Michael J.

In: Critical care medicine, Vol. 45, No. 4, 01.04.2017, p. 584-590.

Research output: Contribution to journalArticle

Traube, C, Silver, G, Reeder, RW, Doyle, H, Hegel, E, Wolfe, HA, Schneller, C, Chung, MG, Dervan, LA, Digennaro, JL, Buttram, SDW, Kudchadkar, SR, Madden, K, Hartman, ME, Dealmeida, ML, Walson, K, Ista, E, Baarslag, MA, Salonia, R, Beca, J, Long, D, Kawai, Y, Cheifetz, IM, Gelvez, J, Truemper, EJ, Smith, RL, Peters, ME, O'Meara, AI, Murphy, S, Bokhary, A, Greenwald, BM & Bell, MJ 2017, 'Delirium in Critically Ill Children: An International Point Prevalence Study∗', Critical care medicine, vol. 45, no. 4, pp. 584-590. https://doi.org/10.1097/CCM.0000000000002250
Traube, Chani ; Silver, Gabrielle ; Reeder, Ron W. ; Doyle, Hannah ; Hegel, Emily ; Wolfe, Heather A. ; Schneller, Christopher ; Chung, Melissa G. ; Dervan, Leslie A. ; Digennaro, Jane L. ; Buttram, Sandra D.W. ; Kudchadkar, Sapna R. ; Madden, Kate ; Hartman, Mary E. ; Dealmeida, Mary L. ; Walson, Karen ; Ista, Erwin ; Baarslag, Manuel A. ; Salonia, Rosanne ; Beca, John ; Long, Debbie ; Kawai, Yu ; Cheifetz, Ira M. ; Gelvez, Javier ; Truemper, Edward J ; Smith, Rebecca L. ; Peters, Megan E. ; O'Meara, Am Iqbal ; Murphy, Sarah ; Bokhary, Abdulmohsen ; Greenwald, Bruce M. ; Bell, Michael J. / Delirium in Critically Ill Children : An International Point Prevalence Study∗. In: Critical care medicine. 2017 ; Vol. 45, No. 4. pp. 584-590.
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AU - Hegel, Emily

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AU - Schneller, Christopher

AU - Chung, Melissa G.

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