Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non- Hodgkin lymphoma

Bhavana J Dave, Diane L. Pickering, Michelle M. Hess, Dennis D. Weisenburger, James Olen Armitage, Warren G. Sanger

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymph area (NHL). The cell division cycle 2-like 1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metephases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58(clk-1) DNA probe. Twenty-three cases exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case, CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalCancer genetics and cytogenetics
Volume108
Issue number2
DOIs
StatePublished - Jan 15 1999

Fingerprint

Non-Hodgkin's Lymphoma
Cell Cycle
Chromosomes
Genes
Lymph
Chromosomes, Human, Pair 1
DNA Probes
Fluorescence In Situ Hybridization
Protein Kinases
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non- Hodgkin lymphoma. / Dave, Bhavana J; Pickering, Diane L.; Hess, Michelle M.; Weisenburger, Dennis D.; Armitage, James Olen; Sanger, Warren G.

In: Cancer genetics and cytogenetics, Vol. 108, No. 2, 15.01.1999, p. 120-126.

Research output: Contribution to journalArticle

Dave, Bhavana J ; Pickering, Diane L. ; Hess, Michelle M. ; Weisenburger, Dennis D. ; Armitage, James Olen ; Sanger, Warren G. / Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non- Hodgkin lymphoma. In: Cancer genetics and cytogenetics. 1999 ; Vol. 108, No. 2. pp. 120-126.
@article{be49d74e56294b7684624a5ea7c8187a,
title = "Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non- Hodgkin lymphoma",
abstract = "Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymph area (NHL). The cell division cycle 2-like 1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metephases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58(clk-1) DNA probe. Twenty-three cases exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case, CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.",
author = "Dave, {Bhavana J} and Pickering, {Diane L.} and Hess, {Michelle M.} and Weisenburger, {Dennis D.} and Armitage, {James Olen} and Sanger, {Warren G.}",
year = "1999",
month = "1",
day = "15",
doi = "10.1016/S0165-4608(98)00138-1",
language = "English (US)",
volume = "108",
pages = "120--126",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non- Hodgkin lymphoma

AU - Dave, Bhavana J

AU - Pickering, Diane L.

AU - Hess, Michelle M.

AU - Weisenburger, Dennis D.

AU - Armitage, James Olen

AU - Sanger, Warren G.

PY - 1999/1/15

Y1 - 1999/1/15

N2 - Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymph area (NHL). The cell division cycle 2-like 1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metephases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58(clk-1) DNA probe. Twenty-three cases exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case, CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.

AB - Our laboratories have documented a significantly high occurrence of chromosome 1p36 rearrangements in non-Hodgkin lymph area (NHL). The cell division cycle 2-like 1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in apoptotic signaling, is located at the very distal region of chromosome 1p36 and is likely to be disrupted by structural rearrangements involving 1p36. To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metephases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58(clk-1) DNA probe. Twenty-three cases exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, the gene locus was translocated to the partner chromosome, and in four specimens, all derived from one case, CDC2L1 was not deleted. This pilot investigation suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene locus, is important in NHL. This work also opens avenues for further molecular studies and prognostic correlations.

UR - http://www.scopus.com/inward/record.url?scp=0033555710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033555710&partnerID=8YFLogxK

U2 - 10.1016/S0165-4608(98)00138-1

DO - 10.1016/S0165-4608(98)00138-1

M3 - Article

C2 - 9973938

AN - SCOPUS:0033555710

VL - 108

SP - 120

EP - 126

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 2

ER -