Degradation modeling of bioabsorbable polymer stent

Pengfei Dong, Longzhen Wang, Linxia Gu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, a computational model of PLLA (Poly L-lactic acid) stent was constructed to study the degradation behavior of the bioabsorbable stent in terms of the loss of mechanical integrity. A degradation model was improved based on experimental data from the literature, as well as a finite element (FE) model was constructed based on the model of the degradation behavior of PLLA material. The results showed that the degradation of the PLLA would switch the material property of stent from a uniform model to a heterogeneous model due to the decline of Young's modulus locally at each location of the stent. Loss of mechanical integrity of the stent showed a bilinear behavior due to the decline of the Young's modulus and the locale failure of the structure, respectively. The breakdown pieces of stent will stay a relative longer time in lesion after the loss of the mechanical integrity of the stent due to the nonlinear response of the degradation degree to the degradation time and strain in the material.

Original languageEnglish (US)
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791852026
DOIs
StatePublished - Jan 1 2018
EventASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018 - Pittsburgh, United States
Duration: Nov 9 2018Nov 15 2018

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume3

Other

OtherASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018
CountryUnited States
CityPittsburgh
Period11/9/1811/15/18

Fingerprint

Stents
Degradation
Polymers
Lactic acid
Elastic moduli
Materials properties
Switches

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Dong, P., Wang, L., & Gu, L. (2018). Degradation modeling of bioabsorbable polymer stent. In Biomedical and Biotechnology Engineering (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 3). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE201888116

Degradation modeling of bioabsorbable polymer stent. / Dong, Pengfei; Wang, Longzhen; Gu, Linxia.

Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME), 2018. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dong, P, Wang, L & Gu, L 2018, Degradation modeling of bioabsorbable polymer stent. in Biomedical and Biotechnology Engineering. ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE), vol. 3, American Society of Mechanical Engineers (ASME), ASME 2018 International Mechanical Engineering Congress and Exposition, IMECE 2018, Pittsburgh, United States, 11/9/18. https://doi.org/10.1115/IMECE201888116
Dong P, Wang L, Gu L. Degradation modeling of bioabsorbable polymer stent. In Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME). 2018. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)). https://doi.org/10.1115/IMECE201888116
Dong, Pengfei ; Wang, Longzhen ; Gu, Linxia. / Degradation modeling of bioabsorbable polymer stent. Biomedical and Biotechnology Engineering. American Society of Mechanical Engineers (ASME), 2018. (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)).
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