Defining larger roles for "tiny" RNA molecules

Role of miRNAs in neurodegeneration research

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Many facets of transcriptional and translational regulation contribute to the proper functioning of the nervous system. Dysfunctional control of mRNA and protein expression can lead to neurodegenerative conditions. Recently, a new regulatory control element-small noncoding RNAs-has been found to play a significant role in many physiologic systems. Here, we review the microRNA (miRNA) field as it pertains to discovery-based and mechanistic studies on the brain and specifically in neurodegenerative disorders. Understanding the role of miRNAs in the brain will aid to open new avenues to the field of neuroscience and, importantly, neurodegenerative disease research.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of Neuroimmune Pharmacology
Volume5
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

MicroRNAs
Neurodegenerative Diseases
RNA
Small Untranslated RNA
Brain
Neurosciences
Research
Nervous System
Messenger RNA
Proteins

Keywords

  • Gene array
  • HIV
  • MRNA
  • MicroRNA
  • Neurodegeneration
  • Neuron
  • Transcriptional regulation
  • Translational regulation

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

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