Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

Y. Zhang, Rana K Zabad, X. Wei, L. M. Metz, M. D. Hill, J. Ross Mitchell

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

Original languageEnglish (US)
Pages (from-to)880-883
Number of pages4
JournalMultiple Sclerosis
Volume13
Issue number7
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Fingerprint

Multiple Sclerosis
Magnetic Resonance Imaging
Globus Pallidus
Caudate Nucleus
Iron
Gray Matter

Keywords

  • Black T2
  • Deep grey matter
  • Disability
  • High field MRI
  • Iron deposition
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis. / Zhang, Y.; Zabad, Rana K; Wei, X.; Metz, L. M.; Hill, M. D.; Mitchell, J. Ross.

In: Multiple Sclerosis, Vol. 13, No. 7, 01.08.2007, p. 880-883.

Research output: Contribution to journalArticle

Zhang, Y. ; Zabad, Rana K ; Wei, X. ; Metz, L. M. ; Hill, M. D. ; Mitchell, J. Ross. / Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis. In: Multiple Sclerosis. 2007 ; Vol. 13, No. 7. pp. 880-883.
@article{e4290a9879814b25bf3db2ac6ef29c7d,
title = "Deep grey matter {"}black T2{"} on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis",
abstract = "T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.",
keywords = "Black T2, Deep grey matter, Disability, High field MRI, Iron deposition, Multiple sclerosis",
author = "Y. Zhang and Zabad, {Rana K} and X. Wei and Metz, {L. M.} and Hill, {M. D.} and Mitchell, {J. Ross}",
year = "2007",
month = "8",
day = "1",
doi = "10.1177/1352458507076411",
language = "English (US)",
volume = "13",
pages = "880--883",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "7",

}

TY - JOUR

T1 - Deep grey matter "black T2" on 3 tesla magnetic resonance imaging correlates with disability in multiple sclerosis

AU - Zhang, Y.

AU - Zabad, Rana K

AU - Wei, X.

AU - Metz, L. M.

AU - Hill, M. D.

AU - Mitchell, J. Ross

PY - 2007/8/1

Y1 - 2007/8/1

N2 - T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

AB - T2 hypointensity (black T2, BT2) in the deep grey matter of multiple sclerosis (MS) patients correlate weakly with disability at 1.5T. BT2 is likely to be caused by abnormal iron deposition. We compared the correlation between disability and deep grey matter BT2 measured on 3T MRI and on 1.5 T MRI in 17 MS patients. We observed a significant correlation between expanded disability status scale and signal intensity on 3 T MRI in the globus pallidus and the caudate nucleus (r = -0.5, P < 0.05). BT2 at 3 T may be a useful MRI measure associated with disability in MS and warrants further study.

KW - Black T2

KW - Deep grey matter

KW - Disability

KW - High field MRI

KW - Iron deposition

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=35848962708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35848962708&partnerID=8YFLogxK

U2 - 10.1177/1352458507076411

DO - 10.1177/1352458507076411

M3 - Article

VL - 13

SP - 880

EP - 883

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 7

ER -