Decreased expression of β1- and β 2-adrenoceptors in human diabetic artrial appendage

U. Deniz Dinçer, Şahika Güner, Aydin Tay, Ebru Arioǧlu, Atilay Taşdelen, Sait Aşlamaci, Keshore R. Bidasee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of β1-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of β 1-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding β1- and β 2-ARs in human atrial tissues. Methods: Right atrial appendages from five diabetic (mean age 65 ± 4.5; 4 female, 1 male) and five nondiabetic patients (mean age5 6.2 ± 2.8; 4 male, 1 female) undergoing coronary artery bypass grafting were collected and assayed using reverse transcriptase-polymerase chain reaction (RTPCR) for their mRNA content. No patient from these two groups suffered from acute myocardial infarction and/or failure. All diabetic patients received insulin for at least two years and had been diagnosed as diabetics for at least five years. Results: When compared with levels in nondiabetics, steady state levels of mRNA encoding β 1-adrenoreceptor decreased by 69.2 ± 7.6 % in diabetic patients while β2-adrenoreceptor mRNA decreased by 32.2 ± 5.5 % (p < 0.001). Conclusions: Our findings show a decreased expression of β1- and β2-adrenoreceptors in human diabetic atrial appendage.

Original languageEnglish (US)
Article number6
JournalCardiovascular Diabetology
Volume2
DOIs
StatePublished - Jun 20 2003

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Adrenergic Receptors
Atrial Appendage
Messenger RNA
Streptozocin
Reverse Transcriptase Polymerase Chain Reaction
Coronary Artery Bypass
Heart Failure
Myocardial Infarction
Insulin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Decreased expression of β1- and β 2-adrenoceptors in human diabetic artrial appendage. / Dinçer, U. Deniz; Güner, Şahika; Tay, Aydin; Arioǧlu, Ebru; Taşdelen, Atilay; Aşlamaci, Sait; Bidasee, Keshore R.

In: Cardiovascular Diabetology, Vol. 2, 6, 20.06.2003.

Research output: Contribution to journalArticle

Dinçer, U. Deniz ; Güner, Şahika ; Tay, Aydin ; Arioǧlu, Ebru ; Taşdelen, Atilay ; Aşlamaci, Sait ; Bidasee, Keshore R. / Decreased expression of β1- and β 2-adrenoceptors in human diabetic artrial appendage. In: Cardiovascular Diabetology. 2003 ; Vol. 2.
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AU - Güner, Şahika

AU - Tay, Aydin

AU - Arioǧlu, Ebru

AU - Taşdelen, Atilay

AU - Aşlamaci, Sait

AU - Bidasee, Keshore R.

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