Decreased Cold-Insoluble Globulin in Congenital Thrombocytopenia (Upshaw-Schulman Syndrome)

Stephen Israel Rennard, S. Abe

Research output: Contribution to journalLetter

27 Citations (Scopus)

Abstract

To the Editor: Cold-insoluble globulin is a plasma protein that coprecipitates with fibrinogen in the cold.1 A closely related protein, fibronectin, is a major constituent of the surface of fibroblasts and other cells and has been the subject of much recent interest.2 Cold-insoluble globulin binds to collagen3,4 and mediates the attachment and spreading of fibroblasts on collagen in vitro.5,6 Recently, Saba et al. have shown that it also mediates the uptake of gelatin-coated particles by the reticuloendothelial system and as such, appears to help the removal of circulating debris after tissue insult.7 Decreased levels of this protein have also followed. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume300
Issue number7
DOIs
StatePublished - Feb 15 1979

Fingerprint

Thrombotic Thrombocytopenic Purpura
Fibronectins
Thrombocytopenia
Fibroblasts
Mononuclear Phagocyte System
Gelatin
Fibrinogen
Blood Proteins
Proteins
Collagen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Decreased Cold-Insoluble Globulin in Congenital Thrombocytopenia (Upshaw-Schulman Syndrome). / Rennard, Stephen Israel; Abe, S.

In: New England Journal of Medicine, Vol. 300, No. 7, 15.02.1979.

Research output: Contribution to journalLetter

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AB - To the Editor: Cold-insoluble globulin is a plasma protein that coprecipitates with fibrinogen in the cold.1 A closely related protein, fibronectin, is a major constituent of the surface of fibroblasts and other cells and has been the subject of much recent interest.2 Cold-insoluble globulin binds to collagen3,4 and mediates the attachment and spreading of fibroblasts on collagen in vitro.5,6 Recently, Saba et al. have shown that it also mediates the uptake of gelatin-coated particles by the reticuloendothelial system and as such, appears to help the removal of circulating debris after tissue insult.7 Decreased levels of this protein have also followed. No extract is available for articles shorter than 400 words.

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