Cytotoxic polyketides with an oxygen-bridged cyclooctadiene core skeleton from the mangrove endophytic fungus phomosis sp. A818

Wei Zhang, Baobing Zhao, Liangcheng Du, Yuemao Shen

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Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5-adenosine monophosphate-activated protein kinase).

Original languageEnglish (US)
Article number1547
Issue number9
Publication statusPublished - Sep 2017



  • Cyclooctadiene
  • Cytotoxicity
  • Endophtic fungus
  • Mycoepoxydiene
  • Polyketide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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