Cytotoxic peripheral T cell lymphoma arising in a patient with nodular lymphocyte predominant hodgkin lymphoma

A case report

Alejandro Arevalo, Gabriel C. Caponetti, Qinglong Hu, Timothy Charles Greiner, Dennis D. Weisenburger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this paper, we describe a case of nodular lymphocyte predominant Hodgkin lymphoma with the subsequent development of a peripheral T cell lymphoma. This case is unusual in that the sheets of atypical and small to intermediate-sized T cells in the diffuse component were CD8 positive and expressed cytotoxic proteins. The diagnosis of peripheral T cell lymphoma was supported by the demonstration of a clonal T cell receptor beta chain gene rearrangement by Southern blot analysis. Peripheral T cell lymphoma with a cytotoxic phenotype is a rare entity with an aggressive clinical behavior. As such, this report emphasizes the need to consider a diagnosis of coexisting peripheral T cell lymphoma in cases of nodular lymphocyte predominant Hodgkin lymphoma with atypical features, such as few or poorly defined B cell macronodules and diffuse T cell areas. The examination of both T cell receptor gamma and beta chain gene rearrangements should be performed to confirm such cases.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalJournal of Hematopathology
Volume3
Issue number1
DOIs
StatePublished - Jun 1 2010

Fingerprint

Peripheral T-Cell Lymphoma
Hodgkin Disease
beta-Chain T-Cell Antigen Receptor Gene Rearrangement
T-Cell Receptor beta Genes
gamma-Chain T-Cell Antigen Receptor Gene Rearrangement
T-Cell Receptor gamma Genes
T-Lymphocytes
Southern Blotting
B-Lymphocytes
Phenotype
Proteins

Keywords

  • Composite lymphoma
  • Cytotoxic peripheral T cell lymphoma
  • Gene rearrangement
  • Hodgkin lymphoma
  • Nodular lymphocyte predominant

ASJC Scopus subject areas

  • Hematology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Cytotoxic peripheral T cell lymphoma arising in a patient with nodular lymphocyte predominant hodgkin lymphoma : A case report. / Arevalo, Alejandro; Caponetti, Gabriel C.; Hu, Qinglong; Greiner, Timothy Charles; Weisenburger, Dennis D.

In: Journal of Hematopathology, Vol. 3, No. 1, 01.06.2010, p. 23-28.

Research output: Contribution to journalArticle

Arevalo, Alejandro ; Caponetti, Gabriel C. ; Hu, Qinglong ; Greiner, Timothy Charles ; Weisenburger, Dennis D. / Cytotoxic peripheral T cell lymphoma arising in a patient with nodular lymphocyte predominant hodgkin lymphoma : A case report. In: Journal of Hematopathology. 2010 ; Vol. 3, No. 1. pp. 23-28.
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