Cytotoxic peripheral T cell lymphoma arising in a patient with nodular lymphocyte predominant hodgkin lymphoma: A case report

Alejandro Arevalo, Gabriel C. Caponetti, Qinglong Hu, Timothy C. Greiner, Dennis D. Weisenburger

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2 Scopus citations


In this paper, we describe a case of nodular lymphocyte predominant Hodgkin lymphoma with the subsequent development of a peripheral T cell lymphoma. This case is unusual in that the sheets of atypical and small to intermediate-sized T cells in the diffuse component were CD8 positive and expressed cytotoxic proteins. The diagnosis of peripheral T cell lymphoma was supported by the demonstration of a clonal T cell receptor beta chain gene rearrangement by Southern blot analysis. Peripheral T cell lymphoma with a cytotoxic phenotype is a rare entity with an aggressive clinical behavior. As such, this report emphasizes the need to consider a diagnosis of coexisting peripheral T cell lymphoma in cases of nodular lymphocyte predominant Hodgkin lymphoma with atypical features, such as few or poorly defined B cell macronodules and diffuse T cell areas. The examination of both T cell receptor gamma and beta chain gene rearrangements should be performed to confirm such cases.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalJournal of Hematopathology
Issue number1
StatePublished - Jun 1 2010



  • Composite lymphoma
  • Cytotoxic peripheral T cell lymphoma
  • Gene rearrangement
  • Hodgkin lymphoma
  • Nodular lymphocyte predominant

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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