Cytoskeletal cytoplasmic filament ribbon of Treponema: A member of an intermediate-like filament protein family

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Development of genetic systems for many bacterial genera, including Treponema, now allow the study of structures that are specific to certain pathogens. The cytoplasmic filament ribbon of treponemes that is involved in the cell division cycle has a unique organization. Cytoplasmic bridging proteins connect the filaments, maintaining the distance between them and providing the overall ribbon-like structure. The filaments are anchored by proteins associated with the inner membrane. Each filament is composed of a unique monomer, the cytoplasmic filament protein A (CfpA), with coiled-coils secondary structures. CfpA is part of a growing family of proteins that we propose to call bacterial intermediate-like filaments (BILF).

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalJournal of Molecular Microbiology and Biotechnology
Volume11
Issue number3-5
DOIs
StatePublished - Sep 1 2006

Fingerprint

Treponema
Intermediate Filament Proteins
Cytoskeleton
Staphylococcal Protein A
Proteins
Intermediate Filaments
Pathogens
Cell Cycle
Monomers
Cells
Membranes

Keywords

  • Bacterial cytoskeleton
  • Cell division
  • Cytoplasmic filament
  • Spirochete

ASJC Scopus subject areas

  • Biotechnology
  • Microbiology
  • Applied Microbiology and Biotechnology
  • Molecular Biology

Cite this

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title = "Cytoskeletal cytoplasmic filament ribbon of Treponema: A member of an intermediate-like filament protein family",
abstract = "Development of genetic systems for many bacterial genera, including Treponema, now allow the study of structures that are specific to certain pathogens. The cytoplasmic filament ribbon of treponemes that is involved in the cell division cycle has a unique organization. Cytoplasmic bridging proteins connect the filaments, maintaining the distance between them and providing the overall ribbon-like structure. The filaments are anchored by proteins associated with the inner membrane. Each filament is composed of a unique monomer, the cytoplasmic filament protein A (CfpA), with coiled-coils secondary structures. CfpA is part of a growing family of proteins that we propose to call bacterial intermediate-like filaments (BILF).",
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T1 - Cytoskeletal cytoplasmic filament ribbon of Treponema

T2 - A member of an intermediate-like filament protein family

AU - Izard, Jacques

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N2 - Development of genetic systems for many bacterial genera, including Treponema, now allow the study of structures that are specific to certain pathogens. The cytoplasmic filament ribbon of treponemes that is involved in the cell division cycle has a unique organization. Cytoplasmic bridging proteins connect the filaments, maintaining the distance between them and providing the overall ribbon-like structure. The filaments are anchored by proteins associated with the inner membrane. Each filament is composed of a unique monomer, the cytoplasmic filament protein A (CfpA), with coiled-coils secondary structures. CfpA is part of a growing family of proteins that we propose to call bacterial intermediate-like filaments (BILF).

AB - Development of genetic systems for many bacterial genera, including Treponema, now allow the study of structures that are specific to certain pathogens. The cytoplasmic filament ribbon of treponemes that is involved in the cell division cycle has a unique organization. Cytoplasmic bridging proteins connect the filaments, maintaining the distance between them and providing the overall ribbon-like structure. The filaments are anchored by proteins associated with the inner membrane. Each filament is composed of a unique monomer, the cytoplasmic filament protein A (CfpA), with coiled-coils secondary structures. CfpA is part of a growing family of proteins that we propose to call bacterial intermediate-like filaments (BILF).

KW - Bacterial cytoskeleton

KW - Cell division

KW - Cytoplasmic filament

KW - Spirochete

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