Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

CD4 T cells have traditionally been regarded as helpers and regulators of adaptive immune responses; however, a novel role for CD4 T cells as direct mediators of protection against viral infections has emerged. CD4 T cells with cytolytic potential have been described for almost 40 years, but their role in host protection against infectious disease is only beginning to be realized. In this review, we describe the current literature identifying these cells in patients with various infections, mouse models of viral infection and our own work investigating the development of cytolytic CD4 cells in vivo and in vitro. CD4 CTL are no longer considered an artefact of cell culture and may play a physiological role in viral infections such as EBV, CMV, HIV and influenza. Therefore, vaccine strategies aimed at targeting CD4 CTL should be developed in conjunction with vaccines incorporating B cell and CD8 CTL epitopes.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalCellular Immunology
Volume262
Issue number2
DOIs
StatePublished - Mar 16 2010

Fingerprint

Virus Diseases
Communicable Diseases
T-Lymphocytes
Vaccines
Neoplasms
Adaptive Immunity
Human Herpesvirus 4
Artifacts
Human Influenza
Epitopes
B-Lymphocytes
Cell Culture Techniques
HIV
Infection

Keywords

  • CD4 T cells
  • Cytotoxicity
  • Granzyme B
  • IL-2
  • Perforin
  • Viral infection

ASJC Scopus subject areas

  • Immunology

Cite this

Cytolytic CD4 cells : Direct mediators in infectious disease and malignancy. / Brown, Deborah M.

In: Cellular Immunology, Vol. 262, No. 2, 16.03.2010, p. 89-95.

Research output: Contribution to journalReview article

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