Cytokines and autoimmunity: Redundancy defines their complex nature

Deepak Yadav, Nora Sarvetnick

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Cytokines are critical mediators in autoimmunity and a better understanding of their mode of action should contribute to the development of strategies for controlling harmful autoimmune reactions. Their complicated nature makes it difficult to classify them as pro- or anti-inflammatory mediators; redundancy in their mode of action has been widely reported. Their complexity is further exemplified by the fact that several cytokines display redundancy in their receptor usage, with the recently identified IL-12 and IL-10 families being prototypical examples. Several aspects - including kinetics of expression, mode of induction, regulation of receptor expression and competition for occupancy, and the stage (acute vs chronic) of the disease - are critical to the net effect, and all these aspects need to be understood if we are to define a cytokine's whole nature.

Original languageEnglish (US)
Pages (from-to)697-703
Number of pages7
JournalCurrent Opinion in Immunology
Volume15
Issue number6
DOIs
StatePublished - Dec 2003

Fingerprint

Autoimmunity
Cytokines
Interleukin-12
Interleukin-10
Chronic Disease
Anti-Inflammatory Agents

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cytokines and autoimmunity : Redundancy defines their complex nature. / Yadav, Deepak; Sarvetnick, Nora.

In: Current Opinion in Immunology, Vol. 15, No. 6, 12.2003, p. 697-703.

Research output: Contribution to journalReview article

@article{80e5d9b0f6d14c12b18a1ac3d095aa32,
title = "Cytokines and autoimmunity: Redundancy defines their complex nature",
abstract = "Cytokines are critical mediators in autoimmunity and a better understanding of their mode of action should contribute to the development of strategies for controlling harmful autoimmune reactions. Their complicated nature makes it difficult to classify them as pro- or anti-inflammatory mediators; redundancy in their mode of action has been widely reported. Their complexity is further exemplified by the fact that several cytokines display redundancy in their receptor usage, with the recently identified IL-12 and IL-10 families being prototypical examples. Several aspects - including kinetics of expression, mode of induction, regulation of receptor expression and competition for occupancy, and the stage (acute vs chronic) of the disease - are critical to the net effect, and all these aspects need to be understood if we are to define a cytokine's whole nature.",
author = "Deepak Yadav and Nora Sarvetnick",
year = "2003",
month = "12",
doi = "10.1016/j.coi.2003.09.006",
language = "English (US)",
volume = "15",
pages = "697--703",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Cytokines and autoimmunity

T2 - Redundancy defines their complex nature

AU - Yadav, Deepak

AU - Sarvetnick, Nora

PY - 2003/12

Y1 - 2003/12

N2 - Cytokines are critical mediators in autoimmunity and a better understanding of their mode of action should contribute to the development of strategies for controlling harmful autoimmune reactions. Their complicated nature makes it difficult to classify them as pro- or anti-inflammatory mediators; redundancy in their mode of action has been widely reported. Their complexity is further exemplified by the fact that several cytokines display redundancy in their receptor usage, with the recently identified IL-12 and IL-10 families being prototypical examples. Several aspects - including kinetics of expression, mode of induction, regulation of receptor expression and competition for occupancy, and the stage (acute vs chronic) of the disease - are critical to the net effect, and all these aspects need to be understood if we are to define a cytokine's whole nature.

AB - Cytokines are critical mediators in autoimmunity and a better understanding of their mode of action should contribute to the development of strategies for controlling harmful autoimmune reactions. Their complicated nature makes it difficult to classify them as pro- or anti-inflammatory mediators; redundancy in their mode of action has been widely reported. Their complexity is further exemplified by the fact that several cytokines display redundancy in their receptor usage, with the recently identified IL-12 and IL-10 families being prototypical examples. Several aspects - including kinetics of expression, mode of induction, regulation of receptor expression and competition for occupancy, and the stage (acute vs chronic) of the disease - are critical to the net effect, and all these aspects need to be understood if we are to define a cytokine's whole nature.

UR - http://www.scopus.com/inward/record.url?scp=0242407712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242407712&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2003.09.006

DO - 10.1016/j.coi.2003.09.006

M3 - Review article

C2 - 14630205

AN - SCOPUS:0242407712

VL - 15

SP - 697

EP - 703

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 6

ER -