Cytogenetics and experimental models

Julia A. Bridge

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Cytogenetic analysis plays a direct, potentially decisive role in the examination of benign and malignant bone and soft tissue tumors. Translocations, or the exchange of chromosomal material between two or more nonhomologous chromosomes, are frequently encountered as tumor-specific anomalies in mesenchymal neoplasms. The consequence of many of these translocations has been the formation of chimeric proteins with features characteristic of altered transcription factors. Recent studies have revealed new tumor-specific translocations (eg, cemento-ossifying fibroma and myxoid chondrosarcoma) and the association of established translocations, eg, t(11;22) and t(12;16), in rare histologic subtypes such as biphenotypic sarcomas with myogenic and with neural differentiation and round cell liposarcoma, respectively. In contrast to a single translocation, many mesenchymal neoplasrns such as malignant fibrous histiocytoma and osteosarcoma are characterized by multiple, often complex, chromosomal abnormalities. Recent advances in molecular cytogenetics, eg, in situ hybridization and comparative genomic hybridization, have made the identification of many of these abnormalities possible and in some instances, have revealed chromosomal imbalances not detectable with traditional cytogenetic analysis.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalCurrent Opinion in Oncology
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1996

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Cytogenetics
Theoretical Models
Cytogenetic Analysis
Neoplasms
Ossifying Fibroma
Malignant Fibrous Histiocytoma
Liposarcoma
Chondrosarcoma
Comparative Genomic Hybridization
Osteosarcoma
Chromosome Aberrations
Sarcoma
In Situ Hybridization
Cell Differentiation
Transcription Factors
Chromosomes
Bone and Bones
Proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cytogenetics and experimental models. / Bridge, Julia A.

In: Current Opinion in Oncology, Vol. 8, No. 4, 01.01.1996, p. 284-288.

Research output: Contribution to journalReview article

Bridge, Julia A. / Cytogenetics and experimental models. In: Current Opinion in Oncology. 1996 ; Vol. 8, No. 4. pp. 284-288.
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