Cytogenetic findings in benign cartilaginous neoplasms

Emilie P. Buddingh, Sabine Naumann, Marilu Nelson, James R. Neff, Nathan Birch, Julia A. Bridge

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Cytogenetic analysis has improved our understanding of the histopathogenesis of many benign and malignant bone and soft tissue tumors, as well as served as an important diagnostic adjunct for these pathologic entities. Cytogenetic reports of benign cartilaginous tumors, however, are relatively few. This is unfortunate, as distinguishing benign and malignant cartilaginous neoplasms can often be difficult. In this study, the cytogenetic findings of two enchondromas, two periosteal chondromas, and one soft part chondroma and a review of the literature are reported. Abnormal diploid or near-diploid clones were detected in all specimens analyzed. Although a tumor-specific anomaly did not emerge from these studies, involvement of certain chromosomes/chromosomal regions appears recurrent.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalCancer genetics and cytogenetics
Volume141
Issue number2
DOIs
StatePublished - Mar 1 2003

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Buddingh, E. P., Naumann, S., Nelson, M., Neff, J. R., Birch, N., & Bridge, J. A. (2003). Cytogenetic findings in benign cartilaginous neoplasms. Cancer genetics and cytogenetics, 141(2), 164-168. https://doi.org/10.1016/S0165-4608(02)00726-4