Cytogenetic findings in benign cartilaginous neoplasms

Emilie P. Buddingh, Sabine Naumann, Marilu Nelson, James R. Neff, Nathan Birch, Julia A. Bridge

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Cytogenetic analysis has improved our understanding of the histopathogenesis of many benign and malignant bone and soft tissue tumors, as well as served as an important diagnostic adjunct for these pathologic entities. Cytogenetic reports of benign cartilaginous tumors, however, are relatively few. This is unfortunate, as distinguishing benign and malignant cartilaginous neoplasms can often be difficult. In this study, the cytogenetic findings of two enchondromas, two periosteal chondromas, and one soft part chondroma and a review of the literature are reported. Abnormal diploid or near-diploid clones were detected in all specimens analyzed. Although a tumor-specific anomaly did not emerge from these studies, involvement of certain chromosomes/chromosomal regions appears recurrent.

Original languageEnglish (US)
Pages (from-to)164-168
Number of pages5
JournalCancer genetics and cytogenetics
Volume141
Issue number2
DOIs
StatePublished - Mar 1 2003

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Chondroma
Cytogenetics
Diploidy
Neoplasms
Cytogenetic Analysis
Clone Cells
Chromosomes
Bone and Bones

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Buddingh, E. P., Naumann, S., Nelson, M., Neff, J. R., Birch, N., & Bridge, J. A. (2003). Cytogenetic findings in benign cartilaginous neoplasms. Cancer genetics and cytogenetics, 141(2), 164-168. https://doi.org/10.1016/S0165-4608(02)00726-4

Cytogenetic findings in benign cartilaginous neoplasms. / Buddingh, Emilie P.; Naumann, Sabine; Nelson, Marilu; Neff, James R.; Birch, Nathan; Bridge, Julia A.

In: Cancer genetics and cytogenetics, Vol. 141, No. 2, 01.03.2003, p. 164-168.

Research output: Contribution to journalArticle

Buddingh, EP, Naumann, S, Nelson, M, Neff, JR, Birch, N & Bridge, JA 2003, 'Cytogenetic findings in benign cartilaginous neoplasms', Cancer genetics and cytogenetics, vol. 141, no. 2, pp. 164-168. https://doi.org/10.1016/S0165-4608(02)00726-4
Buddingh EP, Naumann S, Nelson M, Neff JR, Birch N, Bridge JA. Cytogenetic findings in benign cartilaginous neoplasms. Cancer genetics and cytogenetics. 2003 Mar 1;141(2):164-168. https://doi.org/10.1016/S0165-4608(02)00726-4
Buddingh, Emilie P. ; Naumann, Sabine ; Nelson, Marilu ; Neff, James R. ; Birch, Nathan ; Bridge, Julia A. / Cytogenetic findings in benign cartilaginous neoplasms. In: Cancer genetics and cytogenetics. 2003 ; Vol. 141, No. 2. pp. 164-168.
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