Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis

Julia A. Bridge, Warren G. Sanger, James R. Neff, Michelle M. Hessi

Research output: Contribution to journalArticle

12 Scopus citations


Cytogenetic studies were performed on a malignant fibrous histiocytoma of bone and its metastasis to lung. Numerical chromosome abnormalities were described for all chromosomes except chromosomes 2, 4 and 16. Structural abnormalities in the primary tumor involved chromosomes 1, 3, 5,10,11, 13,15, 16 and 17. The chromosomal rearrangements seen both in the primary tumor and its metastasis involved chromosomes 13,15 and 17. Two X chromosomes contained large homogeneously staining regions (HSRs) in the primary tumor which were replaced by multiple double minutes (DMs) in the metastatic tumor.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
Issue number1
StatePublished - Jan 1990



  • Cytogenetics
  • Double minutes
  • Homogeneously staining region
  • Malignant fibrous histiocytoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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