Cytogenetic analysis of a malignant triton tumor and a malignant peripheral nerve sheath tumor and a review of the literature

Erin N. McComb, Rodney D. McComb, Joanne M. DeBoer, James R. Neff, Julia A. Bridge

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41 Scopus citations

Abstract

Cytogenetic analyses of malignant peripheral nerve sheath tumors (MPNST) and malignant triton tumors (MTT) are few to date. Two separate triton tumor specimens from one patient and a MPNST specimen from another patient, both with peripheral neurofibromatosis (NF-1, von Recklinghausen disease), showed complex near-triploid complements and partial deletion of the short arm of chromosome 1. Notably, a structural abnormality of chromosome 17 was detected in the MPNST, and loss of chromosome 22 was detected in the MTT. The genes for peripheral neurofibromatosis (NF-1) and central neurofibromatosis (NF-2) have been mapped to these two chromosomes respectively.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalCancer genetics and cytogenetics
Volume91
Issue number1
DOIs
StatePublished - Oct 1 1996

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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