Cysteinyl leukotrienes are involved in angiotensin II-induced contraction of aorta from spontaneously hypertensive rats

Stephen A. Spector, Karen Hsia, Florence H. Yong, Sheila Cabral, Terrence Fenton, Courtney V. Fletcher, James McNamara, Lynne M. Mofenson, Stuart E. Starr

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

This study examined the rate of decline in plasma human immunodeficiency virus type 1 (HIV-1) RNA levels to <400 and <50 copies/mL in children receiving highly active antiretroviral therapy (HAART) consisting of efavirenz, nelfinavir, and 1 or 2 nucleoside reverse-transcriptase inhibitors. Children receiving HAART achieved a plasma HIV-1 RNA level <400 copies/mL by a median of 4 weeks after initiation of therapy and a decline to <50 copies/mL by 20 weeks. Baseline plasma HIV-1 RNA levels affected the likelihood of achieving potent and sustained virus suppression, and children whose CD4 lymphocyte counts increased >70 cells/L by 20 weeks on therapy were more likely to achieve durable virological and immunological benefit. These data provide time frames for virus suppression after the initiation of HAART that should be useful in evaluating the potential efficacy and durability of response of newly instituted combination antiretroviral therapy in HIV-1-infected children.

Original languageEnglish (US)
Pages (from-to)152-160
Number of pages9
JournalCardiovascular research
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Angiotensin
  • Arteries
  • Contractile function
  • Hypertension
  • Lipid metabolism
  • Receptors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Spector, S. A., Hsia, K., Yong, F. H., Cabral, S., Fenton, T., Fletcher, C. V., McNamara, J., Mofenson, L. M., & Starr, S. E. (2001). Cysteinyl leukotrienes are involved in angiotensin II-induced contraction of aorta from spontaneously hypertensive rats. Cardiovascular research, 49(1), 152-160. https://doi.org/10.1016/S0008-6363(00)00238-8