Cyclophilin D deficiency prevents diet-induced obesity in mice

Kishor Devalaraja-Narashimha, Alicia M Schiller, Babu J Padanilam

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mitochondrial coupling efficiency is pivotal in thermogenesis and energy homeostasis. Here we show that deletion of cyclophilin D (CypD), a key modulator of the mitochondrial permeability transition pore, demonstrated resistance to diet-induced obesity (DIO) in both male and female mice, due to increased basal metabolic rate, heat production, total energy expenditure and expenditure of fat energy, despite increased food consumption. Absorption of fatty acids is not altered between CypD-/- and wild-type mice. Adult CypD-/- developed hyperglycemia, insulin resistance and glucose intolerance albeit resistant to DIO. These data demonstrate that inhibition of CypD function could protect from HFD-IO by increasing energy expenditure in both male and female mice. Inhibition of CypD may offer a novel target to modulate metabolism.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalFEBS Letters
Volume585
Issue number4
DOIs
StatePublished - Feb 18 2011

Fingerprint

Nutrition
Obesity
Diet
Energy Metabolism
Thermogenesis
Basal Metabolism
Glucose Intolerance
Metabolism
Hyperglycemia
Modulators
Insulin Resistance
Homeostasis
Fatty Acids
Fats
cyclophilin D
Insulin
Glucose
Food

Keywords

  • Adolescent obesity
  • Energy metabolism
  • Mitochondrial uncoupling
  • Permeability transition pore

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Cyclophilin D deficiency prevents diet-induced obesity in mice. / Devalaraja-Narashimha, Kishor; Schiller, Alicia M; Padanilam, Babu J.

In: FEBS Letters, Vol. 585, No. 4, 18.02.2011, p. 677-682.

Research output: Contribution to journalArticle

Devalaraja-Narashimha, Kishor ; Schiller, Alicia M ; Padanilam, Babu J. / Cyclophilin D deficiency prevents diet-induced obesity in mice. In: FEBS Letters. 2011 ; Vol. 585, No. 4. pp. 677-682.
@article{afc6922ce1454796ab617520d2d720c3,
title = "Cyclophilin D deficiency prevents diet-induced obesity in mice",
abstract = "Mitochondrial coupling efficiency is pivotal in thermogenesis and energy homeostasis. Here we show that deletion of cyclophilin D (CypD), a key modulator of the mitochondrial permeability transition pore, demonstrated resistance to diet-induced obesity (DIO) in both male and female mice, due to increased basal metabolic rate, heat production, total energy expenditure and expenditure of fat energy, despite increased food consumption. Absorption of fatty acids is not altered between CypD-/- and wild-type mice. Adult CypD-/- developed hyperglycemia, insulin resistance and glucose intolerance albeit resistant to DIO. These data demonstrate that inhibition of CypD function could protect from HFD-IO by increasing energy expenditure in both male and female mice. Inhibition of CypD may offer a novel target to modulate metabolism.",
keywords = "Adolescent obesity, Energy metabolism, Mitochondrial uncoupling, Permeability transition pore",
author = "Kishor Devalaraja-Narashimha and Schiller, {Alicia M} and Padanilam, {Babu J}",
year = "2011",
month = "2",
day = "18",
doi = "10.1016/j.febslet.2011.01.031",
language = "English (US)",
volume = "585",
pages = "677--682",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Cyclophilin D deficiency prevents diet-induced obesity in mice

AU - Devalaraja-Narashimha, Kishor

AU - Schiller, Alicia M

AU - Padanilam, Babu J

PY - 2011/2/18

Y1 - 2011/2/18

N2 - Mitochondrial coupling efficiency is pivotal in thermogenesis and energy homeostasis. Here we show that deletion of cyclophilin D (CypD), a key modulator of the mitochondrial permeability transition pore, demonstrated resistance to diet-induced obesity (DIO) in both male and female mice, due to increased basal metabolic rate, heat production, total energy expenditure and expenditure of fat energy, despite increased food consumption. Absorption of fatty acids is not altered between CypD-/- and wild-type mice. Adult CypD-/- developed hyperglycemia, insulin resistance and glucose intolerance albeit resistant to DIO. These data demonstrate that inhibition of CypD function could protect from HFD-IO by increasing energy expenditure in both male and female mice. Inhibition of CypD may offer a novel target to modulate metabolism.

AB - Mitochondrial coupling efficiency is pivotal in thermogenesis and energy homeostasis. Here we show that deletion of cyclophilin D (CypD), a key modulator of the mitochondrial permeability transition pore, demonstrated resistance to diet-induced obesity (DIO) in both male and female mice, due to increased basal metabolic rate, heat production, total energy expenditure and expenditure of fat energy, despite increased food consumption. Absorption of fatty acids is not altered between CypD-/- and wild-type mice. Adult CypD-/- developed hyperglycemia, insulin resistance and glucose intolerance albeit resistant to DIO. These data demonstrate that inhibition of CypD function could protect from HFD-IO by increasing energy expenditure in both male and female mice. Inhibition of CypD may offer a novel target to modulate metabolism.

KW - Adolescent obesity

KW - Energy metabolism

KW - Mitochondrial uncoupling

KW - Permeability transition pore

UR - http://www.scopus.com/inward/record.url?scp=79951580824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951580824&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2011.01.031

DO - 10.1016/j.febslet.2011.01.031

M3 - Article

C2 - 21276794

AN - SCOPUS:79951580824

VL - 585

SP - 677

EP - 682

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 4

ER -