Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract

T. Ozaki, S. I. Rennard, R. G. Crystal

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cyclooxygenase metabolites of arachidonic acid are thought to play an important role in the regulation of diverse physiological functions in the lung. Although the concentration of these metabolites required to have effects is several orders of magnitude greater than the concentration of these mediators in the blood, it has been postulated that local concentrations within tissues are much higher. In a direct test of this hypothesis, the concentrations of the cyclooxygenase products of arachidonic acid including prostaglandin (PG) E, PGF(2α), 6-keto-PGF(1α), and thromboxane B2, were measured in a specialized tissue compartment, the epithelial surface of the lower respiratory tract. The concentration of these mediators within this compartment was 50- to 80-fold greater than concurrent blood levels and are sufficient to likely have physiological effects. Thus the epithelial surface of the lower respiratory tract represents a specialized compartment with high local levels of cyclooxygenase products of arachidonic acid.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalJournal of Applied Physiology
Volume62
Issue number1
StatePublished - Jan 1 1987

Fingerprint

Prostaglandin-Endoperoxide Synthases
Respiratory System
Prostaglandins F
Thromboxane B2
Prostaglandins E
Epithelium
Lung

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract. / Ozaki, T.; Rennard, S. I.; Crystal, R. G.

In: Journal of Applied Physiology, Vol. 62, No. 1, 01.01.1987, p. 219-222.

Research output: Contribution to journalArticle

Ozaki, T, Rennard, SI & Crystal, RG 1987, 'Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract', Journal of Applied Physiology, vol. 62, no. 1, pp. 219-222.
Ozaki, T. ; Rennard, S. I. ; Crystal, R. G. / Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract. In: Journal of Applied Physiology. 1987 ; Vol. 62, No. 1. pp. 219-222.
@article{8eaf059248374b0b869d5abde313d3e4,
title = "Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract",
abstract = "Cyclooxygenase metabolites of arachidonic acid are thought to play an important role in the regulation of diverse physiological functions in the lung. Although the concentration of these metabolites required to have effects is several orders of magnitude greater than the concentration of these mediators in the blood, it has been postulated that local concentrations within tissues are much higher. In a direct test of this hypothesis, the concentrations of the cyclooxygenase products of arachidonic acid including prostaglandin (PG) E, PGF(2α), 6-keto-PGF(1α), and thromboxane B2, were measured in a specialized tissue compartment, the epithelial surface of the lower respiratory tract. The concentration of these mediators within this compartment was 50- to 80-fold greater than concurrent blood levels and are sufficient to likely have physiological effects. Thus the epithelial surface of the lower respiratory tract represents a specialized compartment with high local levels of cyclooxygenase products of arachidonic acid.",
author = "T. Ozaki and Rennard, {S. I.} and Crystal, {R. G.}",
year = "1987",
month = "1",
day = "1",
language = "English (US)",
volume = "62",
pages = "219--222",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Cyclooxygenase metabolites are compartmentalized in the human lower respiratory tract

AU - Ozaki, T.

AU - Rennard, S. I.

AU - Crystal, R. G.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Cyclooxygenase metabolites of arachidonic acid are thought to play an important role in the regulation of diverse physiological functions in the lung. Although the concentration of these metabolites required to have effects is several orders of magnitude greater than the concentration of these mediators in the blood, it has been postulated that local concentrations within tissues are much higher. In a direct test of this hypothesis, the concentrations of the cyclooxygenase products of arachidonic acid including prostaglandin (PG) E, PGF(2α), 6-keto-PGF(1α), and thromboxane B2, were measured in a specialized tissue compartment, the epithelial surface of the lower respiratory tract. The concentration of these mediators within this compartment was 50- to 80-fold greater than concurrent blood levels and are sufficient to likely have physiological effects. Thus the epithelial surface of the lower respiratory tract represents a specialized compartment with high local levels of cyclooxygenase products of arachidonic acid.

AB - Cyclooxygenase metabolites of arachidonic acid are thought to play an important role in the regulation of diverse physiological functions in the lung. Although the concentration of these metabolites required to have effects is several orders of magnitude greater than the concentration of these mediators in the blood, it has been postulated that local concentrations within tissues are much higher. In a direct test of this hypothesis, the concentrations of the cyclooxygenase products of arachidonic acid including prostaglandin (PG) E, PGF(2α), 6-keto-PGF(1α), and thromboxane B2, were measured in a specialized tissue compartment, the epithelial surface of the lower respiratory tract. The concentration of these mediators within this compartment was 50- to 80-fold greater than concurrent blood levels and are sufficient to likely have physiological effects. Thus the epithelial surface of the lower respiratory tract represents a specialized compartment with high local levels of cyclooxygenase products of arachidonic acid.

UR - http://www.scopus.com/inward/record.url?scp=0023188941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023188941&partnerID=8YFLogxK

M3 - Article

C2 - 3104286

AN - SCOPUS:0023188941

VL - 62

SP - 219

EP - 222

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 1

ER -