Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression

Weifen Zeng, Kai Fu, Leticia Quintanilla-Fend, Megan Lim, Sarah Ondrejka, Eric D. Hsi

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

SOX11 expression has been recently shown to be useful in the diagnosis of mantle cell lymphoma (MCL), including cyclin D1-negative MCL with typical morphology. We evaluated SOX11 expression pattern in B-cell non-Hodgkin lymphoma (BNHL) subtypes to confirm specificity and used it as a feature to identify the first reported cases of cyclin D1-negative blastoid MCL. SOX11 expression was evaluated by immunohistochemistry in 140 cases of mature B-NHL, including 4 cases of suspected blastoid MCL that lacked cyclin D1 expression and 8 cases of CD5-positive diffuse large B-cell lymphoma (DLBL). In addition, 5 cases of B or T lymphoblastic lymphoma were included. Nuclear expression of SOX11 was found in cyclin D1- positive MCL (30/30, 100%) and in a case of cyclin D1-negative MCL with typical morphology. SOX11 was also expressed in Burkitt lymphoma (1/5, 20%) and lymphoblastic lymphoma (2/3 T-LBLs, 2/2 B-LBLs, overall 4/5, 80%), whereas all cases of DLBL (including CD5+ DLBL) and other small B-NHL were negative. The 4 suspected cases of blastoid MCL were also SOX11+. These cases had a complex karyotype that included 12p abnormalities. We confirmed prior reports that stated that SOX11 nuclear expression was a specific marker for MCL, including cyclin D1-negative MCL with typical morphology. To our knowledge, this is the first report regarding its use in identifying cases of cyclin D1-negative blastoid MCL. Routine use of SOX11 in cases of suspected CD5+ DLBL might help identify additional cases of cyclin D1-negative blastoid MCL.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Mantle-Cell Lymphoma
Cyclin D1
Lymphoma, Large B-Cell, Diffuse
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Burkitt Lymphoma
B-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Karyotype
Non-Hodgkin's Lymphoma
B-Lymphocytes
Immunohistochemistry

Keywords

  • Blastoid
  • Cyclin D1
  • Mantle cell lymphoma
  • SOX11

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. / Zeng, Weifen; Fu, Kai; Quintanilla-Fend, Leticia; Lim, Megan; Ondrejka, Sarah; Hsi, Eric D.

In: American Journal of Surgical Pathology, Vol. 36, No. 2, 01.02.2012, p. 214-219.

Research output: Contribution to journalArticle

Zeng, Weifen ; Fu, Kai ; Quintanilla-Fend, Leticia ; Lim, Megan ; Ondrejka, Sarah ; Hsi, Eric D. / Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. In: American Journal of Surgical Pathology. 2012 ; Vol. 36, No. 2. pp. 214-219.
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