Abstract
The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of CXCL8 and its receptors in melanoma progression and metastasis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | Future Oncology |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2010 |
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Keywords
- CXCL8
- CXCR1
- CXCR2
- Melanoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
CXCL8 and its cognate receptors in melanoma progression and metastasis. / Singh, Seema; Singh, Ajay P.; Sharma, Bhawna; Owen, Laurie B.; Singh, Rakesh K.
In: Future Oncology, Vol. 6, No. 1, 01.02.2010, p. 111-116.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - CXCL8 and its cognate receptors in melanoma progression and metastasis
AU - Singh, Seema
AU - Singh, Ajay P.
AU - Sharma, Bhawna
AU - Owen, Laurie B.
AU - Singh, Rakesh K
PY - 2010/2/1
Y1 - 2010/2/1
N2 - The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of CXCL8 and its receptors in melanoma progression and metastasis.
AB - The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of CXCL8 and its receptors in melanoma progression and metastasis.
KW - CXCL8
KW - CXCR1
KW - CXCR2
KW - Melanoma
UR - http://www.scopus.com/inward/record.url?scp=75149124550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149124550&partnerID=8YFLogxK
U2 - 10.2217/fon.09.128
DO - 10.2217/fon.09.128
M3 - Review article
VL - 6
SP - 111
EP - 116
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 1
ER -