当前对肠道菌群失调对1型糖尿病影响的认识

Translated title of the contribution: Current understanding of the role of gut dysbiosis in type 1 diabetes

Ahmed M. Abdellatif, Nora E Sarvetnick

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin-producing pancreatic β-cells. The disease mainly affects juveniles. Changes in the composition of the gut microbiota (dysbiosis) and changes in the properties of the gut barrier have been documented in T1D subjects. Because these factors affect immune system functions, they are likely to play a role in disease pathogenesis. However, their exact role is currently not fully understood and is under intensive investigation. In this article we discuss recent advancements depicting the role of intestinal dysbiosis on immunity and autoimmunity in T1D. We also discuss therapies aimed at maintaining a healthy gut barrier as prevention strategies for T1D.

Original languageChinese
Pages (from-to)632-644
Number of pages13
JournalJournal of Diabetes
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2019

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Dysbiosis
Type 1 Diabetes Mellitus
Autoimmunity
Immune System
Immunity
Insulin

Keywords

  • autoimmunity
  • dysbiosis
  • gut barrier
  • microbiome
  • type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

当前对肠道菌群失调对1型糖尿病影响的认识. / Abdellatif, Ahmed M.; Sarvetnick, Nora E.

In: Journal of Diabetes, Vol. 11, No. 8, 01.08.2019, p. 632-644.

Research output: Contribution to journalReview article

Abdellatif, Ahmed M. ; Sarvetnick, Nora E. / 当前对肠道菌群失调对1型糖尿病影响的认识. In: Journal of Diabetes. 2019 ; Vol. 11, No. 8. pp. 632-644.
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