Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV

Hussin A. Rothan, Mehdi R.M. Bidokhti, Siddappa Nagadenahalli Byrareddy

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Dissemination of vector-borne viruses, such as Zika virus (ZIKV), in tropical and sub-tropical regions has a complicated impact on the immunopathogenesis of other endemic viruses such as dengue virus (DENV), chikungunya virus (CHIKV) and human immunodeficiency virus (HIV). The consequences of the possible co-infections with these viruses have specifically shown significant impact on the treatment and vaccination strategies. ZIKV is a mosquito-borne flavivirus from African and Asian lineages that causes neurological complications in infected humans. Many of DENV and CHIKV endemic regions have been experiencing outbreaks of ZIKV infection. Intriguingly, the mosquitoes, Aedes Aegypti and Aedes Albopictus, can simultaneously transmit all the combinations of ZIKV, DENV, and CHIKV to the humans. The co-circulation of these viruses leads to a complicated immune response due to the pre-existence or co-existence of ZIKV infection with DENV and CHIKV infections. The non-vector transmission of ZIKV, especially, via sexual intercourse and placenta represents an additional burden that may hander the treatment strategies of other sexually transmitted diseases such as HIV. Collectively, ZIKV co-circulation and co-infection with other viruses have inevitable impact on the host immune response, diagnosis techniques, and vaccine development strategies for the control of these co-infections.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalJournal of Autoimmunity
Volume89
DOIs
StatePublished - May 2018

Fingerprint

Arboviruses
Coinfection
Dengue Virus
Chikungunya virus
HIV
Viruses
Aedes
Culicidae
Flavivirus
Coitus
Sexually Transmitted Diseases
Placenta
Disease Outbreaks
Vaccination
Vaccines
Zika Virus Infection
Zika Virus
Therapeutics

Keywords

  • Chikungunya
  • Co-circulation
  • Co-infection
  • Dengue
  • Flavivirus
  • HIV
  • Vaccination
  • Zika virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Current concerns and perspectives on Zika virus co-infection with arboviruses and HIV. / Rothan, Hussin A.; Bidokhti, Mehdi R.M.; Byrareddy, Siddappa Nagadenahalli.

In: Journal of Autoimmunity, Vol. 89, 05.2018, p. 11-20.

Research output: Contribution to journalReview article

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