Abstract

Small cell lung cancer (SCLC) has a clinical course that is distinct from its more common counterpart non-small cell lung cancer. SCLC continues to be a major clinical problem, with an aggressive clinical course and short disease-free duration after initial therapy. Current optimal treatment consists of chemotherapy with platinum-etoposide, given concurrently with thoracic irradiation in patients with limited stage disease and chemotherapy alone in those with extensive stage. Prophylactic cranial irradiation (PCI) is recommended for patients who have responded to initial therapy, as it not only decreases the risk of brain metastases and but also improves overall survival. Newer targeted agents are currently being evaluated for this disease.

Original languageEnglish (US)
Pages (from-to)1043-1051
Number of pages9
JournalIndian Journal of Medical Research
Volume137
Issue number6
StatePublished - Jun 1 2013

    Fingerprint

Keywords

  • Cisplatin
  • Etoposide
  • Prophylactic cranial irradiation
  • Small cell lung cancer
  • Thoracic radiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this