Current concepts in biofilm formation of Staphylococcus epidermidis

Paul D Fey, Michael E. Olson

Research output: Contribution to journalReview article

203 Citations (Scopus)

Abstract

Staphylococcus epidermidis is a highly significant nosocomial pathogen mediating infections primarily associated with indwelling biomaterials (e.g., catheters and prostheses). In contrast to Staphylococcus aureus, virulence properties associated with S. epidermidis are few and biofilm formation is the defining virulence factor associated with disease, as demonstrated by animal models of biomaterial-related infections. However, other virulence factors, such as phenol-soluble modulins and poly - DL-glutamic acid, have been recently recognized that thwart innate immune system mechanisms. Formation of S. epidermidis biofilm is typically considered a four-step process consisting of adherence, accumulation, maturation and dispersal. This article will discuss recent advances in the study of these four steps, including accumulation, which can be either polysaccharide or protein mediated. It is hypothesized that studies focused on understanding the biological function of each step in staphylococcal biofilm formation will yield new treatment modalities to treat these recalcitrant infections.

Original languageEnglish (US)
Pages (from-to)917-933
Number of pages17
JournalFuture Microbiology
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Staphylococcus epidermidis
Biofilms
Biocompatible Materials
Virulence Factors
Infection
Prostheses and Implants
Polysaccharides
Virulence
Staphylococcus aureus
Glutamic Acid
Immune System
Catheters
Animal Models
Proteins

Keywords

  • Arginine catabolism
  • Biofilm
  • Biofilm maturation
  • Biomaterial-related infections
  • Phenotypic variation
  • Staphylococcus epidermidis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Current concepts in biofilm formation of Staphylococcus epidermidis. / Fey, Paul D; Olson, Michael E.

In: Future Microbiology, Vol. 5, No. 6, 01.06.2010, p. 917-933.

Research output: Contribution to journalReview article

Fey, Paul D ; Olson, Michael E. / Current concepts in biofilm formation of Staphylococcus epidermidis. In: Future Microbiology. 2010 ; Vol. 5, No. 6. pp. 917-933.
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