Cumulative antiretroviral exposure measured in hair is not associated with measures of HIV persistence or inflammation among individuals on suppressive ART

on behalf of the A5321 Team

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Data on the relationship of antiretroviral exposure to measures of human immunodeficiency virus (HIV) persistence are limited. To address this gap, multiple viral, immunologic, and pharmacologic measures were analyzed from individuals with sustained virologic suppression on therapy (median 7 years) in the AIDS Clinical Trials Group A5321 cohort. Among 110 participants on tenofovir-(TFV)-disoproxil-fumarate (TDF)/emtricitabine (FTC)-containing regimens, we found no significant correlation between hair concentrations of individual antiretrovirals (ARVs) in the regimen and measures of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-associated-DNA, cell-associated RNA) or soluble markers of inflammation. These findings suggest that higher systemic ARV exposure may not impact HIV persistence or inflammation.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalJournal of Infectious Diseases
Volume218
Issue number2
DOIs
StatePublished - Jun 20 2018

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Tenofovir
HIV
Inflammation
RNA
HIV-1
Acquired Immunodeficiency Syndrome
Clinical Trials
DNA
Therapeutics
Emtricitabine

Keywords

  • HIV
  • HIV-related inflammation
  • antiretroviral therapy
  • hair concentrations
  • measures of HIV persistence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Cumulative antiretroviral exposure measured in hair is not associated with measures of HIV persistence or inflammation among individuals on suppressive ART. / on behalf of the A5321 Team.

In: Journal of Infectious Diseases, Vol. 218, No. 2, 20.06.2018, p. 234-238.

Research output: Contribution to journalArticle

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abstract = "Data on the relationship of antiretroviral exposure to measures of human immunodeficiency virus (HIV) persistence are limited. To address this gap, multiple viral, immunologic, and pharmacologic measures were analyzed from individuals with sustained virologic suppression on therapy (median 7 years) in the AIDS Clinical Trials Group A5321 cohort. Among 110 participants on tenofovir-(TFV)-disoproxil-fumarate (TDF)/emtricitabine (FTC)-containing regimens, we found no significant correlation between hair concentrations of individual antiretrovirals (ARVs) in the regimen and measures of HIV persistence (plasma HIV-1 RNA by single copy assay, cell-associated-DNA, cell-associated RNA) or soluble markers of inflammation. These findings suggest that higher systemic ARV exposure may not impact HIV persistence or inflammation.",
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