CSF proteomic fingerprints for HIV-associated cognitive impairment

Juliana Pérez Laspiur, Eric R. Anderson, Pawel S Ciborowski, Valerie Wojna, Wojciech Rozek, Fenghai Duan, Raul Mayo, Elaine Rodríguez, Marinés Plaud-Valentín, José Rodríguez-Orengo, Howard Eliot Gendelman, Loyda M. Meléndez

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (CI). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction.

Original languageEnglish (US)
Pages (from-to)157-170
Number of pages14
JournalJournal of Neuroimmunology
Volume192
Issue number1-2
DOIs
StatePublished - Jan 1 2007

Fingerprint

Dermatoglyphics
Proteomics
HIV
HIV-1
Biomarkers
Cerebrospinal Fluid Proteins
Virus Diseases
Hispanic Americans
Proteins
Antioxidants
Cognitive Dysfunction
Therapeutics

Keywords

  • Biomarkers
  • CSF
  • HIV-associated cognitive impairment
  • Proteomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Laspiur, J. P., Anderson, E. R., Ciborowski, P. S., Wojna, V., Rozek, W., Duan, F., ... Meléndez, L. M. (2007). CSF proteomic fingerprints for HIV-associated cognitive impairment. Journal of Neuroimmunology, 192(1-2), 157-170. https://doi.org/10.1016/j.jneuroim.2007.08.004

CSF proteomic fingerprints for HIV-associated cognitive impairment. / Laspiur, Juliana Pérez; Anderson, Eric R.; Ciborowski, Pawel S; Wojna, Valerie; Rozek, Wojciech; Duan, Fenghai; Mayo, Raul; Rodríguez, Elaine; Plaud-Valentín, Marinés; Rodríguez-Orengo, José; Gendelman, Howard Eliot; Meléndez, Loyda M.

In: Journal of Neuroimmunology, Vol. 192, No. 1-2, 01.01.2007, p. 157-170.

Research output: Contribution to journalArticle

Laspiur, JP, Anderson, ER, Ciborowski, PS, Wojna, V, Rozek, W, Duan, F, Mayo, R, Rodríguez, E, Plaud-Valentín, M, Rodríguez-Orengo, J, Gendelman, HE & Meléndez, LM 2007, 'CSF proteomic fingerprints for HIV-associated cognitive impairment', Journal of Neuroimmunology, vol. 192, no. 1-2, pp. 157-170. https://doi.org/10.1016/j.jneuroim.2007.08.004
Laspiur, Juliana Pérez ; Anderson, Eric R. ; Ciborowski, Pawel S ; Wojna, Valerie ; Rozek, Wojciech ; Duan, Fenghai ; Mayo, Raul ; Rodríguez, Elaine ; Plaud-Valentín, Marinés ; Rodríguez-Orengo, José ; Gendelman, Howard Eliot ; Meléndez, Loyda M. / CSF proteomic fingerprints for HIV-associated cognitive impairment. In: Journal of Neuroimmunology. 2007 ; Vol. 192, No. 1-2. pp. 157-170.
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