Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens

Jill R. Blankenship, Nina Singh, Barbara D. Alexander, Joseph Heitman

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.

Original languageEnglish (US)
Pages (from-to)464-467
Number of pages4
JournalJournal of clinical microbiology
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2005

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Cryptococcus neoformans
Tacrolimus
Immunosuppressive Agents
Calcineurin
Cyclosporine
Transplants
Pharmaceutical Preparations
Transplant Recipients
Calcineurin Inhibitors
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. / Blankenship, Jill R.; Singh, Nina; Alexander, Barbara D.; Heitman, Joseph.

In: Journal of clinical microbiology, Vol. 43, No. 1, 01.01.2005, p. 464-467.

Research output: Contribution to journalArticle

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