CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

Lilia G. Noriega, Jérôme N. Feige, Carles Canto, Hiroyasu Yamamoto, Jiujiu Yu, Mark A. Herman, Chikage Mataki, Barbara B. Kahn, Johan Auwerx

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

The nicotinamide adenine dinucleotide (NAD +)-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD +/NADH ratio caused by energy deprivation but also involves an upregulation of SIRT1 mRNA and protein levels in various metabolic tissues. We demonstrate that SIRT1 expression is controlled systemically by the activation of the cyclic AMP response-element-binding protein upon low nutrient availability. Conversely, in the absence of energetic stress, the carbohydrate response-element-binding protein represses the expression of SIRT1. Altogether, these results demonstrate that SIRT1 expression is tightly controlled at the transcriptional level by nutrient availability and further underscore that SIRT1 is a crucial metabolic checkpoint connecting the energetic status with transcriptional programmes.

Original languageEnglish (US)
Pages (from-to)1069-1076
Number of pages8
JournalEMBO Reports
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2011

Fingerprint

NAD
Availability
Nutrients
Fasting
Chemical activation
Food
Cyclic AMP Response Element-Binding Protein
Response Elements
Carrier Proteins
Up-Regulation
Carbohydrates
Tissue
Messenger RNA
Proteins

Keywords

  • CREB
  • ChREBP
  • SIRT1
  • glucagon
  • nutrient availability

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Noriega, L. G., Feige, J. N., Canto, C., Yamamoto, H., Yu, J., Herman, M. A., ... Auwerx, J. (2011). CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Reports, 12(10), 1069-1076. https://doi.org/10.1038/embor.2011.151

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. / Noriega, Lilia G.; Feige, Jérôme N.; Canto, Carles; Yamamoto, Hiroyasu; Yu, Jiujiu; Herman, Mark A.; Mataki, Chikage; Kahn, Barbara B.; Auwerx, Johan.

In: EMBO Reports, Vol. 12, No. 10, 01.10.2011, p. 1069-1076.

Research output: Contribution to journalArticle

Noriega, LG, Feige, JN, Canto, C, Yamamoto, H, Yu, J, Herman, MA, Mataki, C, Kahn, BB & Auwerx, J 2011, 'CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability', EMBO Reports, vol. 12, no. 10, pp. 1069-1076. https://doi.org/10.1038/embor.2011.151
Noriega, Lilia G. ; Feige, Jérôme N. ; Canto, Carles ; Yamamoto, Hiroyasu ; Yu, Jiujiu ; Herman, Mark A. ; Mataki, Chikage ; Kahn, Barbara B. ; Auwerx, Johan. / CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. In: EMBO Reports. 2011 ; Vol. 12, No. 10. pp. 1069-1076.
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