Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

Steven M Tracy, Nora M Chapman, Z. Tu

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

Original languageEnglish (US)
Pages (from-to)399-409
Number of pages11
JournalArchives of Virology
Volume122
Issue number3-4
DOIs
StatePublished - Sep 1 1992

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Enterovirus
Complementary DNA
Genome
Clone Cells
Inbred C3H Mouse
HeLa Cells
Transfection
Amino Acid Sequence
Inflammation
Liver
Serum

ASJC Scopus subject areas

  • Virology

Cite this

Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice. / Tracy, Steven M; Chapman, Nora M; Tu, Z.

In: Archives of Virology, Vol. 122, No. 3-4, 01.09.1992, p. 399-409.

Research output: Contribution to journalArticle

Tracy, Steven M ; Chapman, Nora M ; Tu, Z. / Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice. In: Archives of Virology. 1992 ; Vol. 122, No. 3-4. pp. 399-409.
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