Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

S. Tracy, Nora M. Chapman, Z. Tu

Research output: Contribution to journalArticle

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Abstract

A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

Original languageEnglish (US)
Pages (from-to)399-409
Number of pages11
JournalArchives of Virology
Volume122
Issue number3-4
DOIs
Publication statusPublished - Sep 1 1992

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ASJC Scopus subject areas

  • Virology

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