Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior

Gina L Forster, N. Feng, M. J. Watt, W. J. Korzan, N. J. Mouw, C. H. Summers, K. J. Renner

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The neurotransmitters serotonin and corticotrophin-releasing factor are thought to play an important role in fear and anxiety behaviors. This study aimed to determine the relationship between corticotrophin-releasing factor-evoked changes in serotonin levels within discrete regions of the limbic system and the expression of fear behavior in rats. The effects of corticotrophin-releasing factor administration to the serotonin cell body regions of the dorsal raphe nucleus on fear behavior, behavioral activity, and extracellular serotonin levels were assessed in freely moving rats with microdialysis probes implanted into the central nucleus of the amygdala and the medial prefrontal cortex. Infusion of corticotrophin-releasing factor (0.5 μg) into the dorsal raphe rapidly induced freezing behavior, which was positively correlated with an immediate increase in serotonin release in the central nucleus of the amygdala. In contrast, cessation of freezing behavior correlated with a delayed and prolonged increase in serotonin release within the medial prefrontal cortex. Our findings suggest that corticotrophin-releasing factor-induced freezing behavior is associated with regionally and temporally distinct serotonergic responses in the limbic system that may reflect differing roles for these regions in the expression of fear/anxiety behavior.

Original languageEnglish (US)
Pages (from-to)1047-1055
Number of pages9
JournalNeuroscience
Volume141
Issue number2
DOIs
StatePublished - Jul 21 2006

Fingerprint

Limbic System
Corticotropin-Releasing Hormone
Fear
Serotonin
Freezing
Prefrontal Cortex
Anxiety
Body Regions
Microdialysis
Neurotransmitter Agents
Dorsal Raphe Nucleus

Keywords

  • amygdala
  • anxiety
  • prefrontal cortex
  • stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior. / Forster, Gina L; Feng, N.; Watt, M. J.; Korzan, W. J.; Mouw, N. J.; Summers, C. H.; Renner, K. J.

In: Neuroscience, Vol. 141, No. 2, 21.07.2006, p. 1047-1055.

Research output: Contribution to journalArticle

Forster, Gina L ; Feng, N. ; Watt, M. J. ; Korzan, W. J. ; Mouw, N. J. ; Summers, C. H. ; Renner, K. J. / Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior. In: Neuroscience. 2006 ; Vol. 141, No. 2. pp. 1047-1055.
@article{67e5be7f5d8647bb94841072a496ad55,
title = "Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior",
abstract = "The neurotransmitters serotonin and corticotrophin-releasing factor are thought to play an important role in fear and anxiety behaviors. This study aimed to determine the relationship between corticotrophin-releasing factor-evoked changes in serotonin levels within discrete regions of the limbic system and the expression of fear behavior in rats. The effects of corticotrophin-releasing factor administration to the serotonin cell body regions of the dorsal raphe nucleus on fear behavior, behavioral activity, and extracellular serotonin levels were assessed in freely moving rats with microdialysis probes implanted into the central nucleus of the amygdala and the medial prefrontal cortex. Infusion of corticotrophin-releasing factor (0.5 μg) into the dorsal raphe rapidly induced freezing behavior, which was positively correlated with an immediate increase in serotonin release in the central nucleus of the amygdala. In contrast, cessation of freezing behavior correlated with a delayed and prolonged increase in serotonin release within the medial prefrontal cortex. Our findings suggest that corticotrophin-releasing factor-induced freezing behavior is associated with regionally and temporally distinct serotonergic responses in the limbic system that may reflect differing roles for these regions in the expression of fear/anxiety behavior.",
keywords = "amygdala, anxiety, prefrontal cortex, stress",
author = "Forster, {Gina L} and N. Feng and Watt, {M. J.} and Korzan, {W. J.} and Mouw, {N. J.} and Summers, {C. H.} and Renner, {K. J.}",
year = "2006",
month = "7",
day = "21",
doi = "10.1016/j.neuroscience.2006.04.006",
language = "English (US)",
volume = "141",
pages = "1047--1055",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system in relation to fear behavior

AU - Forster, Gina L

AU - Feng, N.

AU - Watt, M. J.

AU - Korzan, W. J.

AU - Mouw, N. J.

AU - Summers, C. H.

AU - Renner, K. J.

PY - 2006/7/21

Y1 - 2006/7/21

N2 - The neurotransmitters serotonin and corticotrophin-releasing factor are thought to play an important role in fear and anxiety behaviors. This study aimed to determine the relationship between corticotrophin-releasing factor-evoked changes in serotonin levels within discrete regions of the limbic system and the expression of fear behavior in rats. The effects of corticotrophin-releasing factor administration to the serotonin cell body regions of the dorsal raphe nucleus on fear behavior, behavioral activity, and extracellular serotonin levels were assessed in freely moving rats with microdialysis probes implanted into the central nucleus of the amygdala and the medial prefrontal cortex. Infusion of corticotrophin-releasing factor (0.5 μg) into the dorsal raphe rapidly induced freezing behavior, which was positively correlated with an immediate increase in serotonin release in the central nucleus of the amygdala. In contrast, cessation of freezing behavior correlated with a delayed and prolonged increase in serotonin release within the medial prefrontal cortex. Our findings suggest that corticotrophin-releasing factor-induced freezing behavior is associated with regionally and temporally distinct serotonergic responses in the limbic system that may reflect differing roles for these regions in the expression of fear/anxiety behavior.

AB - The neurotransmitters serotonin and corticotrophin-releasing factor are thought to play an important role in fear and anxiety behaviors. This study aimed to determine the relationship between corticotrophin-releasing factor-evoked changes in serotonin levels within discrete regions of the limbic system and the expression of fear behavior in rats. The effects of corticotrophin-releasing factor administration to the serotonin cell body regions of the dorsal raphe nucleus on fear behavior, behavioral activity, and extracellular serotonin levels were assessed in freely moving rats with microdialysis probes implanted into the central nucleus of the amygdala and the medial prefrontal cortex. Infusion of corticotrophin-releasing factor (0.5 μg) into the dorsal raphe rapidly induced freezing behavior, which was positively correlated with an immediate increase in serotonin release in the central nucleus of the amygdala. In contrast, cessation of freezing behavior correlated with a delayed and prolonged increase in serotonin release within the medial prefrontal cortex. Our findings suggest that corticotrophin-releasing factor-induced freezing behavior is associated with regionally and temporally distinct serotonergic responses in the limbic system that may reflect differing roles for these regions in the expression of fear/anxiety behavior.

KW - amygdala

KW - anxiety

KW - prefrontal cortex

KW - stress

UR - http://www.scopus.com/inward/record.url?scp=33745979172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745979172&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2006.04.006

DO - 10.1016/j.neuroscience.2006.04.006

M3 - Article

VL - 141

SP - 1047

EP - 1055

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 2

ER -