Correlation of secondary cytogenetic abnormalities with histologic appearance in non-hodgkin's lymphomas bearing t(14;18)(q32;q21)

James Olen Armitage, W. G. Sanger, D. D. Weisenburger, D. S. Harrington, James Linder, Philip Jay Bierman, Julie Marie Vose, D. T. Purtilo

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Abstract

Successful cytogenetic studies were performed on 69 biopsies from 64 patients with non-Hodgkin's lymphoma bearing a t(14;18)(q32;q21) translocation. This translocation appears to be a primary abnormality associated with the development of certain B-cell non-Hodgkin's lymphomas. We correlated the occurrence of secondary abnormalities, in addition to the t(14;18)(q32;q21), with histologic subtype to test the hypothesis that secondary abnormalities correlate with more aggressive histologic appearance. A large number of secondary abnormalities were identified, the most frequent being additional copies of chromosomes 7 (30%), 12 (22%), 18 (22%), 20 (16%), or 21 (14%), deletion of a portion of the long arm of chromosome 6 (17%), and either an additional chromosome 17 or an isochromosome for the long arm of chromosome 17 (13%). An extra chromosome 7 was highly associated with a diffuse histologic pattern; it was present in 52% of patients with a diffuse pattern and in only 15% of those with a follicular pattern (P = .002). A weaker association with a diffuse growth pattern was found for the addition of chromosome 17 or an i(17q); it was found in 24% of patients with a diffuse pattern and only 5% of those with a follicular pattern (P = .05). No other significant correlations between secondary chromosome abnormalities and histologic subtype were identified. Although the explanation for this association is not clear, it appears that patients with B-cell non-Hodgkin's lymphomas bearing the t(14;18) (q32;q21) translocation which also have an additional chromosome 7 are likely to exhibit a diffuse growth pattern.

Original languageEnglish (US)
Pages (from-to)576-580
Number of pages5
JournalJournal of the National Cancer Institute
Volume80
Issue number8
DOIs
StatePublished - Jun 15 1988

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Chromosomes, Human, Pair 17
Chromosome Aberrations
Non-Hodgkin's Lymphoma
Chromosomes, Human, Pair 7
B-Cell Lymphoma
Isochromosomes
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 6
Growth
Cytogenetics
Biopsy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Correlation of secondary cytogenetic abnormalities with histologic appearance in non-hodgkin's lymphomas bearing t(14;18)(q32;q21). / Armitage, James Olen; Sanger, W. G.; Weisenburger, D. D.; Harrington, D. S.; Linder, James; Bierman, Philip Jay; Vose, Julie Marie; Purtilo, D. T.

In: Journal of the National Cancer Institute, Vol. 80, No. 8, 15.06.1988, p. 576-580.

Research output: Contribution to journalArticle

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abstract = "Successful cytogenetic studies were performed on 69 biopsies from 64 patients with non-Hodgkin's lymphoma bearing a t(14;18)(q32;q21) translocation. This translocation appears to be a primary abnormality associated with the development of certain B-cell non-Hodgkin's lymphomas. We correlated the occurrence of secondary abnormalities, in addition to the t(14;18)(q32;q21), with histologic subtype to test the hypothesis that secondary abnormalities correlate with more aggressive histologic appearance. A large number of secondary abnormalities were identified, the most frequent being additional copies of chromosomes 7 (30{\%}), 12 (22{\%}), 18 (22{\%}), 20 (16{\%}), or 21 (14{\%}), deletion of a portion of the long arm of chromosome 6 (17{\%}), and either an additional chromosome 17 or an isochromosome for the long arm of chromosome 17 (13{\%}). An extra chromosome 7 was highly associated with a diffuse histologic pattern; it was present in 52{\%} of patients with a diffuse pattern and in only 15{\%} of those with a follicular pattern (P = .002). A weaker association with a diffuse growth pattern was found for the addition of chromosome 17 or an i(17q); it was found in 24{\%} of patients with a diffuse pattern and only 5{\%} of those with a follicular pattern (P = .05). No other significant correlations between secondary chromosome abnormalities and histologic subtype were identified. Although the explanation for this association is not clear, it appears that patients with B-cell non-Hodgkin's lymphomas bearing the t(14;18) (q32;q21) translocation which also have an additional chromosome 7 are likely to exhibit a diffuse growth pattern.",
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AU - Harrington, D. S.

AU - Linder, James

AU - Bierman, Philip Jay

AU - Vose, Julie Marie

AU - Purtilo, D. T.

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