Corpus luteum and early pregnancy in ruminants

Thomas R. Hansen, Rebecca Bott, Jared Romero, Alfredo Antoniazzi, John S Davis

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This review examines the function of the corpus luteum (CL) with emphasis on pregnancy in ruminant models and the possible impact of pregnancy in conferring luteal resistance to prostaglandin F2α (PGF2α). Critical processes involved with formation of the CL impact the capacity to secrete progesterone. Similarly, complete luteolysis is critically important in the event that pregnancy does not occur so that a new ovulation and opportunity for pregnancy is established. It is well known that serum progesterone must reach a critical nadir if ovulation and fertilization are to occur. Following fertilization, the function of the CL in providing adequate progesterone is critical in setting up an endometrial environment so that pregnancy is maintained. Benefi ts of supplemental progesterone during early pregnancy are inconsistent in ruminants. However, recent studies indicate that supplemental progesterone following artifi cial insemination (AI) may depend on the presence of the CL and the amount of progesterone released from the CL. The primary signal for maternal recognition of pregnancy, interferon-tau (IFNT), is secreted from the ruminant conceptus (embryo proper and extraembryonic membranes). IFNT disrupts release of PGF2α from the endometrium and is antiluteolytic through inhibiting uterine expression of the estradiol receptor (ESR1) or the oxytocin receptor (OXTR). Endocrine action of IFNT on peripheral blood mononuclear cells and on the CL may also contribute to immunomodulatory function and longer-term sustainability and function of the CL as pregnancy progresses.

Original languageEnglish (US)
Title of host publicationThe Life Cycle of the Corpus Luteum
PublisherSpringer International Publishing
Pages205-225
Number of pages21
ISBN (Electronic)9783319432380
ISBN (Print)9783319432366
DOIs
StatePublished - Jan 1 2016

Fingerprint

Corpus Luteum
Ruminants
corpus luteum
ruminants
pregnancy
Progesterone
Pregnancy
progesterone
interferons
Dinoprost
fertilization (reproduction)
Ovulation
Fertilization
prostaglandins
ovulation
Oxytocin Receptors
Estradiol Receptors
Luteolysis
Extraembryonic Membranes
extraembryonic membranes

Keywords

  • Corpus luteum
  • Interferon
  • Interferonstimulated genes
  • Leukocytes
  • Peripheral blood mononuclear cells
  • Pregnancy
  • Ruminants

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hansen, T. R., Bott, R., Romero, J., Antoniazzi, A., & Davis, J. S. (2016). Corpus luteum and early pregnancy in ruminants. In The Life Cycle of the Corpus Luteum (pp. 205-225). Springer International Publishing. https://doi.org/10.1007/978-3-319-43238-0_11

Corpus luteum and early pregnancy in ruminants. / Hansen, Thomas R.; Bott, Rebecca; Romero, Jared; Antoniazzi, Alfredo; Davis, John S.

The Life Cycle of the Corpus Luteum. Springer International Publishing, 2016. p. 205-225.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hansen, TR, Bott, R, Romero, J, Antoniazzi, A & Davis, JS 2016, Corpus luteum and early pregnancy in ruminants. in The Life Cycle of the Corpus Luteum. Springer International Publishing, pp. 205-225. https://doi.org/10.1007/978-3-319-43238-0_11
Hansen TR, Bott R, Romero J, Antoniazzi A, Davis JS. Corpus luteum and early pregnancy in ruminants. In The Life Cycle of the Corpus Luteum. Springer International Publishing. 2016. p. 205-225 https://doi.org/10.1007/978-3-319-43238-0_11
Hansen, Thomas R. ; Bott, Rebecca ; Romero, Jared ; Antoniazzi, Alfredo ; Davis, John S. / Corpus luteum and early pregnancy in ruminants. The Life Cycle of the Corpus Luteum. Springer International Publishing, 2016. pp. 205-225
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