Converting modified Health Assessment Questionnaire (HAQ), multidimensional HAQ, and HAQII scores into original HAQ scores using models developed with a large cohort of rheumatoid arthritis patients

Jaclyn Anderson, Harlan Sayles, Jeffrey R. Curtis, Fred Wolfe, Kaleb D Michaud

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective. The Stanford Health Assessment Questionnaire Disability Index (HAQ) is the gold standard functional status questionnaire in rheumatology, but it is lengthy. Three shorter versions, the modified HAQ (MHAQ), the Multidimensional HAQ (MDHAQ), and the HAQII are often used in outcomes research as HAQ substitutes. We developed conversion formulas between these modified versions and the original HAQ. Methods. Analysis was limited to the comparison of rheumatoid arthritis (RA) patients at a random observation when the HAQ was recorded in conjunction with the MHAQ (n = 29,596), the MDHAQ (n = 13,665), or the HAQII (n = 15,823). Development models were randomly limited to 80% of the data (development sample) and the remaining 20% was used for model validation. Results. Two conversion formulas were developed for each of the MHAQ, the MDHAQ, and the HAQII: a short model and a long model inclusive of questions common to both the modified measures and the original HAQ. Short models explained 81-83%, and long models 82-86%, of the variance. Predicted HAQ values of zero were assigned to all cases with an MDHAQ or HAQII score of zero, with remaining cases used for model estimation. Bland-Altman plots demonstrated good concordance between actual and predicted values for each measure. The validation sample closely approximated the results from the development sample (0.005 ≤ ΔR 2 ≤ 0.009) for each measure. Conclusion. We have developed and validated highly accurate conversion formulas from the MHAQ, MDHAQ, and HAQII to the original HAQ in a large sample of RA patients. The developed models are useful for conversion of measures in the research setting. Because of substantial variability at the individual patient level, application of the formulas to individual patients is inadvisable.

Original languageEnglish (US)
Pages (from-to)1481-1488
Number of pages8
JournalArthritis Care and Research
Volume62
Issue number10
DOIs
StatePublished - Oct 1 2010

Fingerprint

ametantrone
Rheumatoid Arthritis
Health
Surveys and Questionnaires
Rheumatology

ASJC Scopus subject areas

  • Rheumatology

Cite this

Converting modified Health Assessment Questionnaire (HAQ), multidimensional HAQ, and HAQII scores into original HAQ scores using models developed with a large cohort of rheumatoid arthritis patients. / Anderson, Jaclyn; Sayles, Harlan; Curtis, Jeffrey R.; Wolfe, Fred; Michaud, Kaleb D.

In: Arthritis Care and Research, Vol. 62, No. 10, 01.10.2010, p. 1481-1488.

Research output: Contribution to journalArticle

@article{9b3cba8eaf634e4e970911952a5818dc,
title = "Converting modified Health Assessment Questionnaire (HAQ), multidimensional HAQ, and HAQII scores into original HAQ scores using models developed with a large cohort of rheumatoid arthritis patients",
abstract = "Objective. The Stanford Health Assessment Questionnaire Disability Index (HAQ) is the gold standard functional status questionnaire in rheumatology, but it is lengthy. Three shorter versions, the modified HAQ (MHAQ), the Multidimensional HAQ (MDHAQ), and the HAQII are often used in outcomes research as HAQ substitutes. We developed conversion formulas between these modified versions and the original HAQ. Methods. Analysis was limited to the comparison of rheumatoid arthritis (RA) patients at a random observation when the HAQ was recorded in conjunction with the MHAQ (n = 29,596), the MDHAQ (n = 13,665), or the HAQII (n = 15,823). Development models were randomly limited to 80{\%} of the data (development sample) and the remaining 20{\%} was used for model validation. Results. Two conversion formulas were developed for each of the MHAQ, the MDHAQ, and the HAQII: a short model and a long model inclusive of questions common to both the modified measures and the original HAQ. Short models explained 81-83{\%}, and long models 82-86{\%}, of the variance. Predicted HAQ values of zero were assigned to all cases with an MDHAQ or HAQII score of zero, with remaining cases used for model estimation. Bland-Altman plots demonstrated good concordance between actual and predicted values for each measure. The validation sample closely approximated the results from the development sample (0.005 ≤ ΔR 2 ≤ 0.009) for each measure. Conclusion. We have developed and validated highly accurate conversion formulas from the MHAQ, MDHAQ, and HAQII to the original HAQ in a large sample of RA patients. The developed models are useful for conversion of measures in the research setting. Because of substantial variability at the individual patient level, application of the formulas to individual patients is inadvisable.",
author = "Jaclyn Anderson and Harlan Sayles and Curtis, {Jeffrey R.} and Fred Wolfe and Michaud, {Kaleb D}",
year = "2010",
month = "10",
day = "1",
doi = "10.1002/acr.20265",
language = "English (US)",
volume = "62",
pages = "1481--1488",
journal = "Arthritis and Rheumatism",
issn = "2151-4658",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - Converting modified Health Assessment Questionnaire (HAQ), multidimensional HAQ, and HAQII scores into original HAQ scores using models developed with a large cohort of rheumatoid arthritis patients

AU - Anderson, Jaclyn

AU - Sayles, Harlan

AU - Curtis, Jeffrey R.

AU - Wolfe, Fred

AU - Michaud, Kaleb D

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Objective. The Stanford Health Assessment Questionnaire Disability Index (HAQ) is the gold standard functional status questionnaire in rheumatology, but it is lengthy. Three shorter versions, the modified HAQ (MHAQ), the Multidimensional HAQ (MDHAQ), and the HAQII are often used in outcomes research as HAQ substitutes. We developed conversion formulas between these modified versions and the original HAQ. Methods. Analysis was limited to the comparison of rheumatoid arthritis (RA) patients at a random observation when the HAQ was recorded in conjunction with the MHAQ (n = 29,596), the MDHAQ (n = 13,665), or the HAQII (n = 15,823). Development models were randomly limited to 80% of the data (development sample) and the remaining 20% was used for model validation. Results. Two conversion formulas were developed for each of the MHAQ, the MDHAQ, and the HAQII: a short model and a long model inclusive of questions common to both the modified measures and the original HAQ. Short models explained 81-83%, and long models 82-86%, of the variance. Predicted HAQ values of zero were assigned to all cases with an MDHAQ or HAQII score of zero, with remaining cases used for model estimation. Bland-Altman plots demonstrated good concordance between actual and predicted values for each measure. The validation sample closely approximated the results from the development sample (0.005 ≤ ΔR 2 ≤ 0.009) for each measure. Conclusion. We have developed and validated highly accurate conversion formulas from the MHAQ, MDHAQ, and HAQII to the original HAQ in a large sample of RA patients. The developed models are useful for conversion of measures in the research setting. Because of substantial variability at the individual patient level, application of the formulas to individual patients is inadvisable.

AB - Objective. The Stanford Health Assessment Questionnaire Disability Index (HAQ) is the gold standard functional status questionnaire in rheumatology, but it is lengthy. Three shorter versions, the modified HAQ (MHAQ), the Multidimensional HAQ (MDHAQ), and the HAQII are often used in outcomes research as HAQ substitutes. We developed conversion formulas between these modified versions and the original HAQ. Methods. Analysis was limited to the comparison of rheumatoid arthritis (RA) patients at a random observation when the HAQ was recorded in conjunction with the MHAQ (n = 29,596), the MDHAQ (n = 13,665), or the HAQII (n = 15,823). Development models were randomly limited to 80% of the data (development sample) and the remaining 20% was used for model validation. Results. Two conversion formulas were developed for each of the MHAQ, the MDHAQ, and the HAQII: a short model and a long model inclusive of questions common to both the modified measures and the original HAQ. Short models explained 81-83%, and long models 82-86%, of the variance. Predicted HAQ values of zero were assigned to all cases with an MDHAQ or HAQII score of zero, with remaining cases used for model estimation. Bland-Altman plots demonstrated good concordance between actual and predicted values for each measure. The validation sample closely approximated the results from the development sample (0.005 ≤ ΔR 2 ≤ 0.009) for each measure. Conclusion. We have developed and validated highly accurate conversion formulas from the MHAQ, MDHAQ, and HAQII to the original HAQ in a large sample of RA patients. The developed models are useful for conversion of measures in the research setting. Because of substantial variability at the individual patient level, application of the formulas to individual patients is inadvisable.

UR - http://www.scopus.com/inward/record.url?scp=77957687303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957687303&partnerID=8YFLogxK

U2 - 10.1002/acr.20265

DO - 10.1002/acr.20265

M3 - Article

C2 - 20496428

AN - SCOPUS:77957687303

VL - 62

SP - 1481

EP - 1488

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

SN - 2151-4658

IS - 10

ER -