Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes

Tahir Majid, Corey R. Hopkins, Brian Pedgrift, Nicola Collar

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A convenient one-step protocol for the synthesis of 4-amino-3,5- disubstituted pyrazoles has been developed. This method employs readily available diketo oximes as starting materials, and employs hydrazine hydrate for the cyclization and subsequent reduction of the intermediate nitroso compound.

Original languageEnglish (US)
Pages (from-to)2137-2139
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number10
DOIs
StatePublished - Mar 1 2004

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hydrazine
Pyrazoles
Nitroso Compounds
Oximes
Cyclization

Keywords

  • Hydrazine hydrate
  • Pyrazole
  • Reduction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Convenient synthesis of 4-amino-3,5-disubstituted pyrazoles in one step from the corresponding diketo oximes. / Majid, Tahir; Hopkins, Corey R.; Pedgrift, Brian; Collar, Nicola.

In: Tetrahedron Letters, Vol. 45, No. 10, 01.03.2004, p. 2137-2139.

Research output: Contribution to journalArticle

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