Control of the renal microvasculature by vasoactive peptides

Pamela K Carmines, J. T. Fleming

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

In recent years, numerous techniques have been developed to study renal microcirculation. These technical advances have provided new insight regarding the specificity of action of vasoconstrictor peptides (angiotensin II, arginine vasopressin, endothelin) and vasodilator peptides (bradykinin, atrial natriuretic peptide) at discrete sites within the renal vascular bed. Differential signal transduction mechanisms, particularly those related to calcium regulation, appear to mediate the renal vascular actions of these compounds, both in a segment-specific and agonist-specific manner. These observations substantiate the concept that regulation of intrarenal and intraglomerular dynamics is accomplished by selective changes in pre- and postglomerular resistance induced by different endogenous peptides. This microvascular selectivity allows precise regulation of glomerular and peritubular capillary function, and ultimately exerts great influence on the volume and composition of the final urine.

Original languageEnglish (US)
Pages (from-to)3300-3309
Number of pages10
JournalFASEB Journal
Volume4
Issue number15
StatePublished - Dec 1 1990

Fingerprint

Microvessels
kidneys
peptides
Kidney
blood vessels
Peptides
Blood Vessels
Microcirculation
arginine vasopressin
atrial natriuretic peptide
vasoconstrictor agents
bradykinin
Signal transduction
vasodilator agents
endothelins
angiotensin II
Arginine Vasopressin
induced resistance
Endothelins
Atrial Natriuretic Factor

Keywords

  • Angiotensin II
  • Arginine vasopressin
  • Atrial natriuretic peptide
  • Bradykinin
  • Calcium
  • Endothelin
  • Renal microcirculation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Control of the renal microvasculature by vasoactive peptides. / Carmines, Pamela K; Fleming, J. T.

In: FASEB Journal, Vol. 4, No. 15, 01.12.1990, p. 3300-3309.

Research output: Contribution to journalReview article

Carmines, PK & Fleming, JT 1990, 'Control of the renal microvasculature by vasoactive peptides', FASEB Journal, vol. 4, no. 15, pp. 3300-3309.
Carmines, Pamela K ; Fleming, J. T. / Control of the renal microvasculature by vasoactive peptides. In: FASEB Journal. 1990 ; Vol. 4, No. 15. pp. 3300-3309.
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