Control of the autoimmune response by type 2 nitric oxide synthase

F. D. Shi, M. Flodström, Ha Kim Soon Ha Kim, S. Pakala, M. Cleary, H. G. Ljunggren, Nora E Sarvetnick

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Immune defense against pathogens often requires NO, synthesized by type 2 NO synthase (NOS2). To discern whether this axis could participate in an autoimmune response, we immunized NOS2-deficient mice with the autoantigen acetylcholine receptor, inducing muscle weakness characteristic of myasthenia gravis, a T cell-dependent Ab-mediated autoimmune disease. We found that the acetylcholine receptor-immunized NOS2-deficient mice developed an exacerbated form of myasthenia gravis, and demonstrated that NOS2 expression limits autoreactive T cell determinant spreading and diversification of the autoantibody repertoire, a process driven by macrophages. Thus, NOS2/NO is important for silencing autoreactive T cells and may restrict bystander autoimmune reactions following the innate immune response.

Original languageEnglish (US)
Pages (from-to)3000-3006
Number of pages7
JournalJournal of Immunology
Volume167
Issue number5
DOIs
StatePublished - Sep 1 2001
Externally publishedYes

Fingerprint

Nitric Oxide Synthase Type II
Autoimmunity
Myasthenia Gravis
Cholinergic Receptors
T-Lymphocytes
Muscle Weakness
Autoantigens
Innate Immunity
Nitric Oxide Synthase
Autoantibodies
Autoimmune Diseases
Macrophages

ASJC Scopus subject areas

  • Immunology

Cite this

Shi, F. D., Flodström, M., Soon Ha Kim, H. K., Pakala, S., Cleary, M., Ljunggren, H. G., & Sarvetnick, N. E. (2001). Control of the autoimmune response by type 2 nitric oxide synthase. Journal of Immunology, 167(5), 3000-3006. https://doi.org/10.4049/jimmunol.167.5.3000

Control of the autoimmune response by type 2 nitric oxide synthase. / Shi, F. D.; Flodström, M.; Soon Ha Kim, Ha Kim; Pakala, S.; Cleary, M.; Ljunggren, H. G.; Sarvetnick, Nora E.

In: Journal of Immunology, Vol. 167, No. 5, 01.09.2001, p. 3000-3006.

Research output: Contribution to journalArticle

Shi, FD, Flodström, M, Soon Ha Kim, HK, Pakala, S, Cleary, M, Ljunggren, HG & Sarvetnick, NE 2001, 'Control of the autoimmune response by type 2 nitric oxide synthase', Journal of Immunology, vol. 167, no. 5, pp. 3000-3006. https://doi.org/10.4049/jimmunol.167.5.3000
Shi FD, Flodström M, Soon Ha Kim HK, Pakala S, Cleary M, Ljunggren HG et al. Control of the autoimmune response by type 2 nitric oxide synthase. Journal of Immunology. 2001 Sep 1;167(5):3000-3006. https://doi.org/10.4049/jimmunol.167.5.3000
Shi, F. D. ; Flodström, M. ; Soon Ha Kim, Ha Kim ; Pakala, S. ; Cleary, M. ; Ljunggren, H. G. ; Sarvetnick, Nora E. / Control of the autoimmune response by type 2 nitric oxide synthase. In: Journal of Immunology. 2001 ; Vol. 167, No. 5. pp. 3000-3006.
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