Control of intracellular calcium levels

Shyamala Dakshinamurti, Jonathan Geiger, Krishnamurti Dakshinamurti

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Calcium is arguably the most versatile and universal second messenger. As such, calcium plays a key signaling role in cells. The coupling of membrane excitation to cellular responses through calcium has long been recognized.l As an intracellular second messenger, cytosolic free calcium regulates, directly or indirectly, vital cellular functions. Physiological and pathological processes such as fertilization, proliferation, metabolism, membrane excitability, neurotransmitter release, synaptic plasticity, gene transcription, muscle contraction, neuronal injury through ischemia, epilepsy, and trauma, as well as cell death by necrosis or apoptosis, all involve calcium-mediated mechanisms. Thus, mechanisms that regulate calcium homeostasis are central to physiological and pathophysiological processes. In this chapter, cellular calcium influx and calcium release from the endo/sarcoplasmic reticulum and their control by various intracellular metabolites are discussed.

Original languageEnglish (US)
Title of host publicationNutrients and Cell Signaling
PublisherCRC Press
Pages589-620
Number of pages32
ISBN (Electronic)9781420028362
ISBN (Print)9780824722487
Publication statusPublished - Jan 1 2005

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ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dakshinamurti, S., Geiger, J., & Dakshinamurti, K. (2005). Control of intracellular calcium levels. In Nutrients and Cell Signaling (pp. 589-620). CRC Press.