Contribution of QSART to the diagnosis of small fiber neuropathy.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We evaluated incorporation of the quantitative sudomotor axon reflex test (QSART) into the diagnostic criteria for small fiber neuropathy (SFN) as an addition to quantitative sensory testing (QST) and intraepidermal nerve fiber density (IENFD) testing. One hundred one patients with clinically suspected SFN underwent QSART, QST, and skin biopsy. The diagnostic yield of existing SFN criteria in these patients was compared with criteria incorporating QSART. The new combined diagnostic criteria were evaluated. SFN was diagnosed in 38 of the 101 patients (38%) using current criteria. Addition of QSART existing SFN criteria resulted in an increased diagnostic yield to 67 patients (66%). Applying new SFN criteria requiring abnormality in at least 2 assessments among QSART, QST, and IENFD resulted in a diagnosis of SFN in 57 patients (56%). Assessment of both somatic and peripheral autonomic small nerve fibers enhances diagnostic criteria for SFN.

Original languageEnglish (US)
Pages (from-to)883-888
Number of pages6
JournalMuscle & nerve
Volume48
Issue number6
StatePublished - Jan 1 2013

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Axons
Reflex
Nerve Fibers
Autonomic Pathways
Small Fiber Neuropathy
Routine Diagnostic Tests
Biopsy
Skin

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Contribution of QSART to the diagnosis of small fiber neuropathy. / Thaisetthawatkul, Pariwat; Fernandes Filho, Jose Americo M; Herrmann, David N.

In: Muscle & nerve, Vol. 48, No. 6, 01.01.2013, p. 883-888.

Research output: Contribution to journalArticle

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