Contribution of Fiber Undulation to Mechanics of Three-Dimensional Collagen-I Gel

Shengmao Lin, Linxia Gu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The collagen-I gel is extensively used as a scaffold material in tissue engineering due to its ability to mimic the extracellular matrix (ECM). In this study, the mechanics of collagen-I gel is investigated using a numerical model of three-dimensional collagen network. The resulted mechanical behavior was validated against the published experimental data. Results illustrated that fiber alignment was dominated in the low strain region, and its transition to stretching dominated phenomena at higher strain led to the strain stiffening of collagen gel. The collagen undulation at the microscopic level was found to delay the initiation of strain stiffening.

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalMacromolecular Symposia
Volume365
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

collagens
Collagen
Mechanics
Gels
gels
fibers
Fibers
stiffening
tissue engineering
Scaffolds (biology)
Tissue engineering
Stretching
Numerical models
alignment
matrices

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Contribution of Fiber Undulation to Mechanics of Three-Dimensional Collagen-I Gel. / Lin, Shengmao; Gu, Linxia.

In: Macromolecular Symposia, Vol. 365, No. 1, 01.07.2016, p. 112-117.

Research output: Contribution to journalArticle

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