Continuous non-invasive monitoring to detect covert autonomic dysfunction in Parkinson's disease

Amy M. Hellman, Shital P. Shah, Stephanie M. Pawlowski, John E. Duda, James F. Morley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Lightheadedness on standing is a disabling symptom in Parkinson's disease associated with orthostatic hypotension and is thought to represent cardiovascular autonomic dysfunction. Traditional orthostatic blood pressures are normal in some patients with lightheadedness and other measures of cardiovascular dysautonomia can be insensitive. In this study, we used continuous non-invasive arterial pressure monitoring to measure beat-to-beat changes in blood pressure and heart rate on standing and during Valsalva as a potential marker of autonomic dysfunction. Methods: Subjects had a diagnosis of Parkinson's disease with or without documented orthostatic hypotension. Each participant underwent traditional measurement of orthostatic blood pressure and heart rate as well as measurement of beat-to-beat blood pressure and heart rate using continuous non-invasive arterial pressure monitoring during Valsalva maneuver and in response to standing. Orthostatic change in blood pressure and heart rate, and frequencies of normal and abnormal blood pressure responses to Valsalva maneuver were analyzed. Results: In subjects without documented orthostatic hypotension, there was a higher proportion of abnormal blood pressure responses to Valsalva in subjects with symptoms of lightheadedness or dizziness upon standing compared to those without symptoms (p=0.03). Additionally, the proportion of abnormal blood pressure responses during Valsalva observed in symptomatic subjects without orthostatic hypotension was indistinguishable from those with documented orthostatic hypotension (p=0.7). Conclusions: Our findings suggest that continuous non-invasive arterial pressure monitoring may be more sensitive than traditional measurement of orthostatic blood pressure to detect subtle cardiac dysautonomia in Parkinson's disease and helpful in the diagnosis of unexplained lightheadedness.

Original languageEnglish (US)
Pages (from-to)723-728
Number of pages6
JournalParkinsonism and Related Disorders
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Parkinson Disease
Orthostatic Hypotension
Blood Pressure
Dizziness
Heart Rate
Primary Dysautonomias
Valsalva Maneuver
Arterial Pressure

Keywords

  • Autonomic dysfunction
  • Orthostatic hypotension
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Continuous non-invasive monitoring to detect covert autonomic dysfunction in Parkinson's disease. / Hellman, Amy M.; Shah, Shital P.; Pawlowski, Stephanie M.; Duda, John E.; Morley, James F.

In: Parkinsonism and Related Disorders, Vol. 21, No. 7, 01.07.2015, p. 723-728.

Research output: Contribution to journalArticle

Hellman, Amy M. ; Shah, Shital P. ; Pawlowski, Stephanie M. ; Duda, John E. ; Morley, James F. / Continuous non-invasive monitoring to detect covert autonomic dysfunction in Parkinson's disease. In: Parkinsonism and Related Disorders. 2015 ; Vol. 21, No. 7. pp. 723-728.
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