Considerations for comprehensive assessment of genetic predisposition in familial breast cancer

Henry Lynch, Carrie Synder, San Ming Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

About 10-15% of breast cancer cases are family related, classified as familial breast cancer. The disease was first reported in 1866 and determined to be an autosomal dominant genetic disease in 1971. Germline mutations in BRCA1 were discovered and deemed as the first genetic predisposition for the disease in 1994. By now, genetic predispositions for about 40% of familial breast cancer families have been identified. New molecular genetic approaches currently under development should accelerate the process to identify the full spectrum of genetic predispositions for the disease, thereby enabling a better understanding of the genetic basis of the disease and therein providing benefit to high-risk patients.

Original languageEnglish (US)
Pages (from-to)67-75
Number of pages9
JournalBreast Journal
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2015

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Inborn Genetic Diseases
Genetic Predisposition to Disease
Germ-Line Mutation
Molecular Biology
Breast Neoplasms
Familial Breast Cancer

Keywords

  • BRCA1
  • BRCA2
  • exome sequencing
  • hereditary breast cancer
  • predisposition

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology
  • Surgery
  • Medicine(all)

Cite this

Considerations for comprehensive assessment of genetic predisposition in familial breast cancer. / Lynch, Henry; Synder, Carrie; Wang, San Ming.

In: Breast Journal, Vol. 21, No. 1, 01.01.2015, p. 67-75.

Research output: Contribution to journalArticle

Lynch, Henry ; Synder, Carrie ; Wang, San Ming. / Considerations for comprehensive assessment of genetic predisposition in familial breast cancer. In: Breast Journal. 2015 ; Vol. 21, No. 1. pp. 67-75.
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