Congenital lymphocytic choriomeningitis virus infection: Spectrum of disease

Daniel J. Bonthius, Rhonda R Wright, Brian Tseng, Leslie Barton, Elysa Marco, Bahri Karacay, Paul D. Larsen

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective: Lymphocytic choriomeningitis virus (LCMV) is a human pathogen and an emerging neuroteratogen. When the infection occurs during pregnancy, the virus can target and damage the fetal brain and retina. We examined the spectrum of clinical presentations, neuroimaging findings, and clinical outcomes of children with congenital LCMV infection. Methods: Twenty children with serologically confirmed congenital LCMV infection were identified. The children underwent neuroimaging studies and were followed prospectively for up to 11 years. Results: All children with congenital LCMV infection had chorioretinitis and structural brain anomalies. However, the presenting clinical signs, severity of vision disturbance, nature and location of neuropathology, and character and severity of brain dysfunction varied substantially among cases. Neuroimaging abnormalities included microencephaly, periventricular calcifications, ventriculomegaly, pachygyria, cerebellar hypoplasia, porencephalic cysts, periventricular cysts, and hydrocephalus. The combination of microencephaly and periventricular calcifications was the most common neuroimaging abnormality, and all children with this combination had profound mental retardation, epilepsy, and cerebral palsy. However, others had less severe neuroimaging abnormalities and better outcomes. Some children had isolated cerebellar hypoplasia, with jitteriness as their presenting sign and ataxia as their principal long-term neurological dysfunction. Interpretation: Congenital LCMV infection can have diverse presenting signs, neuroimaging abnormalities, and clinical outcomes. In the companion article to this study, we utilize an animal model to show that the clinical and pathological diversity in congenital LCMV infection is likely due to differences in the gestational timing of infection.

Original languageEnglish (US)
Pages (from-to)347-355
Number of pages9
JournalAnnals of Neurology
Volume62
Issue number4
DOIs
StatePublished - Oct 1 2007

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Lymphocytic choriomeningitis virus
Virus Diseases
Neuroimaging
Cysts
Brain
Lissencephaly
Chorioretinitis
Cerebral Palsy
Ataxia
Hydrocephalus
Infection
Intellectual Disability
Retina
Epilepsy
Animal Models
Viruses
Pregnancy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bonthius, D. J., Wright, R. R., Tseng, B., Barton, L., Marco, E., Karacay, B., & Larsen, P. D. (2007). Congenital lymphocytic choriomeningitis virus infection: Spectrum of disease. Annals of Neurology, 62(4), 347-355. https://doi.org/10.1002/ana.21161

Congenital lymphocytic choriomeningitis virus infection : Spectrum of disease. / Bonthius, Daniel J.; Wright, Rhonda R; Tseng, Brian; Barton, Leslie; Marco, Elysa; Karacay, Bahri; Larsen, Paul D.

In: Annals of Neurology, Vol. 62, No. 4, 01.10.2007, p. 347-355.

Research output: Contribution to journalArticle

Bonthius, DJ, Wright, RR, Tseng, B, Barton, L, Marco, E, Karacay, B & Larsen, PD 2007, 'Congenital lymphocytic choriomeningitis virus infection: Spectrum of disease', Annals of Neurology, vol. 62, no. 4, pp. 347-355. https://doi.org/10.1002/ana.21161
Bonthius, Daniel J. ; Wright, Rhonda R ; Tseng, Brian ; Barton, Leslie ; Marco, Elysa ; Karacay, Bahri ; Larsen, Paul D. / Congenital lymphocytic choriomeningitis virus infection : Spectrum of disease. In: Annals of Neurology. 2007 ; Vol. 62, No. 4. pp. 347-355.
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