Congenital cytomegalovirus infection

Alexander K.C. Leung, Reginald S. Sauve, Herbert Dele Davies

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) is the most common congenital infection in humans. Congenital CMV infection can follow either a primary or recurrent maternal infection, but the likelihood of fetal infection and the risk of associated damage is higher after a primary infection. Approximately 90% of congenitally infected infants are asymptomatic at birth. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. More frequent and more severe sequelae occur in symptomatic infants, notably psychomotor hearing loss and retardation. Congenital CMV infection can be diagnosed by isolation of the virus from the urine or saliva within the first three weeks of life. Rapid diagnosis can be accomplished by detection of CMV DNA by DNA amplification or hybridization techniques.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalJournal of the National Medical Association
Volume95
Issue number3
StatePublished - Mar 1 2003

Fingerprint

Cytomegalovirus Infections
Infection
Cytomegalovirus
Purpura
DNA
Jaundice
Hearing Loss
Saliva
Mothers
Urine
Parturition
Viruses

Keywords

  • Cytomegalovirus
  • Hearing loss
  • Primary and recurrent infection
  • Psychomotor retardation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Congenital cytomegalovirus infection. / Leung, Alexander K.C.; Sauve, Reginald S.; Davies, Herbert Dele.

In: Journal of the National Medical Association, Vol. 95, No. 3, 01.03.2003, p. 213-218.

Research output: Contribution to journalReview article

Leung, AKC, Sauve, RS & Davies, HD 2003, 'Congenital cytomegalovirus infection', Journal of the National Medical Association, vol. 95, no. 3, pp. 213-218.
Leung, Alexander K.C. ; Sauve, Reginald S. ; Davies, Herbert Dele. / Congenital cytomegalovirus infection. In: Journal of the National Medical Association. 2003 ; Vol. 95, No. 3. pp. 213-218.
@article{974632c4c7b04942861c8150eeca2561,
title = "Congenital cytomegalovirus infection",
abstract = "Cytomegalovirus (CMV) is the most common congenital infection in humans. Congenital CMV infection can follow either a primary or recurrent maternal infection, but the likelihood of fetal infection and the risk of associated damage is higher after a primary infection. Approximately 90{\%} of congenitally infected infants are asymptomatic at birth. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. More frequent and more severe sequelae occur in symptomatic infants, notably psychomotor hearing loss and retardation. Congenital CMV infection can be diagnosed by isolation of the virus from the urine or saliva within the first three weeks of life. Rapid diagnosis can be accomplished by detection of CMV DNA by DNA amplification or hybridization techniques.",
keywords = "Cytomegalovirus, Hearing loss, Primary and recurrent infection, Psychomotor retardation",
author = "Leung, {Alexander K.C.} and Sauve, {Reginald S.} and Davies, {Herbert Dele}",
year = "2003",
month = "3",
day = "1",
language = "English (US)",
volume = "95",
pages = "213--218",
journal = "Journal of the National Medical Association",
issn = "1943-4693",
publisher = "National Medical Association",
number = "3",

}

TY - JOUR

T1 - Congenital cytomegalovirus infection

AU - Leung, Alexander K.C.

AU - Sauve, Reginald S.

AU - Davies, Herbert Dele

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Cytomegalovirus (CMV) is the most common congenital infection in humans. Congenital CMV infection can follow either a primary or recurrent maternal infection, but the likelihood of fetal infection and the risk of associated damage is higher after a primary infection. Approximately 90% of congenitally infected infants are asymptomatic at birth. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. More frequent and more severe sequelae occur in symptomatic infants, notably psychomotor hearing loss and retardation. Congenital CMV infection can be diagnosed by isolation of the virus from the urine or saliva within the first three weeks of life. Rapid diagnosis can be accomplished by detection of CMV DNA by DNA amplification or hybridization techniques.

AB - Cytomegalovirus (CMV) is the most common congenital infection in humans. Congenital CMV infection can follow either a primary or recurrent maternal infection, but the likelihood of fetal infection and the risk of associated damage is higher after a primary infection. Approximately 90% of congenitally infected infants are asymptomatic at birth. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. More frequent and more severe sequelae occur in symptomatic infants, notably psychomotor hearing loss and retardation. Congenital CMV infection can be diagnosed by isolation of the virus from the urine or saliva within the first three weeks of life. Rapid diagnosis can be accomplished by detection of CMV DNA by DNA amplification or hybridization techniques.

KW - Cytomegalovirus

KW - Hearing loss

KW - Primary and recurrent infection

KW - Psychomotor retardation

UR - http://www.scopus.com/inward/record.url?scp=0037705328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037705328&partnerID=8YFLogxK

M3 - Review article

VL - 95

SP - 213

EP - 218

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

SN - 1943-4693

IS - 3

ER -