Congenital anemia, dyskeratosis, and progressive alopecia in Polled Hereford calves.

D. J. Steffen, H. W. Leipold, J. Gibb, J. E. Smith

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A new syndrome of anemia, alopecia, and dyskeratosis was identified in Polled Hereford calves in this study. Cutaneous changes included hyperkeratosis and hair loss around the muzzle and ear margins, which progressed to a generalized alopecia and hyperkeratotic dermatitis. Histologically, orthokeratotic hyperkeratosis with dyskeratosis of epidermal and follicular keratinocytes was present. Alopecia was correlated with dyskeratosis of Huxley's layer and an increasing proportion of follicles in the telogen phase of the hair cycle. Dermatitis was characterized by a mild dermal mononuclear cell infiltrate and mild lymphocytic perivascular dermatitis. The anemia present at birth was nonprogressive and was classified as normochromic and normocytic to macrocytic. Reticulocytosis was absent, but bone marrow was markedly hyperplastic. Nuclear cytoplasmic asynchrony of the rubricyte and metarubricyte stages occurred in the bone marrow. Abnormal rubricyte nuclei and maturation arrest at the late rubricyte stage were common. Cytologic features of the erythroid series are similar to those of type I congenital dyserythropoietic anemia of human beings. Genealogic features suggest that this is a primary hereditary defect. The mode of inheritance, however, remains to be determined.

Original languageEnglish (US)
Pages (from-to)234-240
Number of pages7
JournalVeterinary pathology
Volume28
Issue number3
DOIs
StatePublished - May 1991

Fingerprint

Polled Hereford
alopecia
Alopecia
anemia
Anemia
Dermatitis
dermatitis
calves
hyperkeratosis
bone marrow
Congenital Dyserythropoietic Anemia
Bone Marrow
Reticulocytosis
Skin
keratinocytes
Keratinocytes
Hair
hairs
Ear
ears

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Congenital anemia, dyskeratosis, and progressive alopecia in Polled Hereford calves. / Steffen, D. J.; Leipold, H. W.; Gibb, J.; Smith, J. E.

In: Veterinary pathology, Vol. 28, No. 3, 05.1991, p. 234-240.

Research output: Contribution to journalArticle

Steffen, D. J. ; Leipold, H. W. ; Gibb, J. ; Smith, J. E. / Congenital anemia, dyskeratosis, and progressive alopecia in Polled Hereford calves. In: Veterinary pathology. 1991 ; Vol. 28, No. 3. pp. 234-240.
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