Conductive core-sheath nanofibers and their potential application in neural tissue engineering

Jingwei Xie, Matthew R. MacEwcm, Stephanie M. Willerth, Xiaoran Li, Daniel W. Moran, Shelly E. Sakiyama-Elbert, Younan Xia

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Conductive core-sheath nanofibers are prepared by a combination of electrospinning and aqueous polymerization. Specifically, nanofibers electrospun from poly(ε-caprolactone) (PCL) and poly(1-lactide) (PLA) are employed as templates to generate uniform sheaths of polypyrrole (PPy) by in-situ polymerization. These conductive core-sheath nanofibers offer a unique system to study the synergistic effect of different cues on neurite outgrowth in vitro. It is found that explanted dorsal root ganglia (DRC) adhere well to the conductive core-sheath nanofibers and generate neurites across the surface when there is a nerve growth factor in the medium. Furthermore, the neurites can be oriented along one direction and enhanced by 82% in terms of maximum length when uniaxially aligned conductive core-sheath nanofibers are compared with their random counterparts. Electrical stimulation, when applied through the mats of conductive core-sheath nanofibers, is found to further increase the maximum length of neurites for random and aligned samples by 83% and 47%, respectively, relative to the controls without electrical stimulation. Together these results suggest the potential use of the conductive core-sheath nanofibers as scaffolds in applications such as neural tissue engineering.

Original languageEnglish (US)
Pages (from-to)2312-2318
Number of pages7
JournalAdvanced Functional Materials
Volume19
Issue number14
DOIs
StatePublished - Jul 24 2009

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tissue engineering
Bioelectric potentials
Nanofibers
Tissue engineering
sheaths
stimulation
Discoverer recovery capsules
polymerization
Polymerization
polypyrroles
cues
Polypyrroles
Electrospinning
nerves
Nerve Growth Factor
Scaffolds (biology)
templates

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Xie, J., MacEwcm, M. R., Willerth, S. M., Li, X., Moran, D. W., Sakiyama-Elbert, S. E., & Xia, Y. (2009). Conductive core-sheath nanofibers and their potential application in neural tissue engineering. Advanced Functional Materials, 19(14), 2312-2318. https://doi.org/10.1002/adfm.200801904

Conductive core-sheath nanofibers and their potential application in neural tissue engineering. / Xie, Jingwei; MacEwcm, Matthew R.; Willerth, Stephanie M.; Li, Xiaoran; Moran, Daniel W.; Sakiyama-Elbert, Shelly E.; Xia, Younan.

In: Advanced Functional Materials, Vol. 19, No. 14, 24.07.2009, p. 2312-2318.

Research output: Contribution to journalArticle

Xie, J, MacEwcm, MR, Willerth, SM, Li, X, Moran, DW, Sakiyama-Elbert, SE & Xia, Y 2009, 'Conductive core-sheath nanofibers and their potential application in neural tissue engineering', Advanced Functional Materials, vol. 19, no. 14, pp. 2312-2318. https://doi.org/10.1002/adfm.200801904
Xie, Jingwei ; MacEwcm, Matthew R. ; Willerth, Stephanie M. ; Li, Xiaoran ; Moran, Daniel W. ; Sakiyama-Elbert, Shelly E. ; Xia, Younan. / Conductive core-sheath nanofibers and their potential application in neural tissue engineering. In: Advanced Functional Materials. 2009 ; Vol. 19, No. 14. pp. 2312-2318.
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