Concurrent Zidovudine Levels in Semen and Serum Determined by Radioimmunoassay in Patients With AIDS or AIDS-Related Complex

Keith Henry, Barbara J. Chinnock, Richard P. Quinn, Courtney V. Fletcher, Paulo Miranda, Henry H. Balfour

Research output: Contribution to journalArticle

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Abstract

Zidovudine was present in the semen and serum of six patients with acquired immunodeficiency syndrome or the related complex who were receiving 200 mg of the drug orally every four to six hours. Mean semen zidovudine levels (as measured by a new radioimmunoassay) in samples collected 0.75 to 1.25 hours after oral dosing were 3.63 to 7.19 μmol/L. Levels in semen samples collected 3.0 to 4.5 hours after oral dosing were 1.68 to 6.43 μmol/L. These values are above the in vitro minimum inhibitory concentration for the human immunodeficiency virus type 1 (HIV-1). Mean serum concentrations at the early and late times after oral dosing were 0.22 to 3.07 μmol/L and 0.10 to 1.42 μmol/L, respectively. Ratios of semen/serum zidovudine levels ranged from 1.3 to 20.4. It is possible that a pH-dependent trapping mechanism, which has been described in the prostate for other antibiotics, was responsible for the relatively high semen levels observed.

Original languageEnglish (US)
Pages (from-to)3023-3026
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume259
Issue number20
DOIs
StatePublished - May 27 1988

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AIDS-Related Complex
Zidovudine
Semen
Radioimmunoassay
Acquired Immunodeficiency Syndrome
Serum
Microbial Sensitivity Tests
HIV-1
Prostate
Anti-Bacterial Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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Concurrent Zidovudine Levels in Semen and Serum Determined by Radioimmunoassay in Patients With AIDS or AIDS-Related Complex. / Henry, Keith; Chinnock, Barbara J.; Quinn, Richard P.; Fletcher, Courtney V.; Miranda, Paulo; Balfour, Henry H.

In: JAMA: The Journal of the American Medical Association, Vol. 259, No. 20, 27.05.1988, p. 3023-3026.

Research output: Contribution to journalArticle

Henry, Keith ; Chinnock, Barbara J. ; Quinn, Richard P. ; Fletcher, Courtney V. ; Miranda, Paulo ; Balfour, Henry H. / Concurrent Zidovudine Levels in Semen and Serum Determined by Radioimmunoassay in Patients With AIDS or AIDS-Related Complex. In: JAMA: The Journal of the American Medical Association. 1988 ; Vol. 259, No. 20. pp. 3023-3026.
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