Concordant expression of tissue factor and class II MHC antigens in human placental endothelium

Carlos A. Labarrere, Charles T. Esmon, Steven D Carson, W. Page Faulk

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Villitis of unestablished etiology is a placental lesion frequently associated with high risk pregnancies: it is also found in placentae from normal term pregnancies. The etiology of the lesion is unknown. Vasculitis and thrombosis have been described in villitis areas of placentae from normal and high risk pregnancies. We asked if fetal stem vessel endothelium in villitis lesions expresses MHC class II antigens, and if this is associated with a thrombogenic activity of these vessels. We found that endothelium of fetal stem vessels in villitis areas was usually MHC class II (HLA-DR, DP and DQ) reactive. Reactivity of fetal stem vessel endothelium for MHC class II antigens was associated with the presence of tissue factor reactivity and the absence of thrombomodulin reactivity. These changes on endothelial plasma membranes can promote intravascular coagulation, ischemic necrosis, vasculitis and other histological changes characteristic of villitis.

Original languageEnglish (US)
Pages (from-to)309-318
Number of pages10
JournalPlacenta
Volume11
Issue number4
DOIs
StatePublished - Jan 1 1990

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Histocompatibility Antigens Class II
Thromboplastin
Endothelium
High-Risk Pregnancy
Vasculitis
Placenta
HLA-DP Antigens
HLA-DQ Antigens
Thrombomodulin
HLA-DR Antigens
Thrombosis
Necrosis
Cell Membrane
Pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Concordant expression of tissue factor and class II MHC antigens in human placental endothelium. / Labarrere, Carlos A.; Esmon, Charles T.; Carson, Steven D; Faulk, W. Page.

In: Placenta, Vol. 11, No. 4, 01.01.1990, p. 309-318.

Research output: Contribution to journalArticle

Labarrere, Carlos A. ; Esmon, Charles T. ; Carson, Steven D ; Faulk, W. Page. / Concordant expression of tissue factor and class II MHC antigens in human placental endothelium. In: Placenta. 1990 ; Vol. 11, No. 4. pp. 309-318.
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