Concise review: The Sox2-Oct4 connection: Critical players in a much larger interdependent network integrated at multiple levels

Research output: Contribution to journalShort survey

62 Citations (Scopus)

Abstract

The transcription factors Sox2 and Oct4 have been a major focus of stem cell biology since the discovery, more than 10 years ago, that they play critical roles during embryogenesis. Early work established that these two transcription factors work together to regulate genes required for the self-renewal and pluripotency of embryonic stem cells (ESC). Surprisingly, small changes (∼twofold) in the levels of either Oct4 or Sox2 induce the differentiation of ESC. Consequently, ESC must maintain the levels of these two transcription factors within narrow limits. Genome-wide binding studies and unbiased proteomic screens have been conducted to decipher the complex roles played by Oct4 and Sox2 in the transcriptional circuitry of ESC. Together, these and other studies provide a comprehensive understanding of the molecular machinery that sustains the self-renewal of ESC and restrains their differentiation. Importantly, these studies paint a landscape in which Oct4 and Sox2 are part of a much larger interdependent network composed of many transcription factors that are interconnected at multiple levels of function.

Original languageEnglish (US)
Pages (from-to)1033-1039
Number of pages7
JournalSTEM CELLS
Volume31
Issue number6
DOIs
StatePublished - Jun 1 2013

Fingerprint

Embryonic Stem Cells
Transcription Factors
Paint
Proteomics
Embryonic Development
Cell Biology
Stem Cells
Genome
Genes

Keywords

  • Dna repair
  • Embryonic stem cells
  • Gene regulatory networks
  • Induced pluripotent stem cells
  • Oct4
  • Proteomics
  • Reprogramming
  • Self-renewal
  • Sox2
  • Transcription factors
  • Transcriptional circuitry

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Concise review : The Sox2-Oct4 connection: Critical players in a much larger interdependent network integrated at multiple levels. / Rizzino, A Angie.

In: STEM CELLS, Vol. 31, No. 6, 01.06.2013, p. 1033-1039.

Research output: Contribution to journalShort survey

@article{d9ada013580a4f73b495492bad17feaa,
title = "Concise review: The Sox2-Oct4 connection: Critical players in a much larger interdependent network integrated at multiple levels",
abstract = "The transcription factors Sox2 and Oct4 have been a major focus of stem cell biology since the discovery, more than 10 years ago, that they play critical roles during embryogenesis. Early work established that these two transcription factors work together to regulate genes required for the self-renewal and pluripotency of embryonic stem cells (ESC). Surprisingly, small changes (∼twofold) in the levels of either Oct4 or Sox2 induce the differentiation of ESC. Consequently, ESC must maintain the levels of these two transcription factors within narrow limits. Genome-wide binding studies and unbiased proteomic screens have been conducted to decipher the complex roles played by Oct4 and Sox2 in the transcriptional circuitry of ESC. Together, these and other studies provide a comprehensive understanding of the molecular machinery that sustains the self-renewal of ESC and restrains their differentiation. Importantly, these studies paint a landscape in which Oct4 and Sox2 are part of a much larger interdependent network composed of many transcription factors that are interconnected at multiple levels of function.",
keywords = "Dna repair, Embryonic stem cells, Gene regulatory networks, Induced pluripotent stem cells, Oct4, Proteomics, Reprogramming, Self-renewal, Sox2, Transcription factors, Transcriptional circuitry",
author = "Rizzino, {A Angie}",
year = "2013",
month = "6",
day = "1",
doi = "10.1002/stem.1352",
language = "English (US)",
volume = "31",
pages = "1033--1039",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press",
number = "6",

}

TY - JOUR

T1 - Concise review

T2 - The Sox2-Oct4 connection: Critical players in a much larger interdependent network integrated at multiple levels

AU - Rizzino, A Angie

PY - 2013/6/1

Y1 - 2013/6/1

N2 - The transcription factors Sox2 and Oct4 have been a major focus of stem cell biology since the discovery, more than 10 years ago, that they play critical roles during embryogenesis. Early work established that these two transcription factors work together to regulate genes required for the self-renewal and pluripotency of embryonic stem cells (ESC). Surprisingly, small changes (∼twofold) in the levels of either Oct4 or Sox2 induce the differentiation of ESC. Consequently, ESC must maintain the levels of these two transcription factors within narrow limits. Genome-wide binding studies and unbiased proteomic screens have been conducted to decipher the complex roles played by Oct4 and Sox2 in the transcriptional circuitry of ESC. Together, these and other studies provide a comprehensive understanding of the molecular machinery that sustains the self-renewal of ESC and restrains their differentiation. Importantly, these studies paint a landscape in which Oct4 and Sox2 are part of a much larger interdependent network composed of many transcription factors that are interconnected at multiple levels of function.

AB - The transcription factors Sox2 and Oct4 have been a major focus of stem cell biology since the discovery, more than 10 years ago, that they play critical roles during embryogenesis. Early work established that these two transcription factors work together to regulate genes required for the self-renewal and pluripotency of embryonic stem cells (ESC). Surprisingly, small changes (∼twofold) in the levels of either Oct4 or Sox2 induce the differentiation of ESC. Consequently, ESC must maintain the levels of these two transcription factors within narrow limits. Genome-wide binding studies and unbiased proteomic screens have been conducted to decipher the complex roles played by Oct4 and Sox2 in the transcriptional circuitry of ESC. Together, these and other studies provide a comprehensive understanding of the molecular machinery that sustains the self-renewal of ESC and restrains their differentiation. Importantly, these studies paint a landscape in which Oct4 and Sox2 are part of a much larger interdependent network composed of many transcription factors that are interconnected at multiple levels of function.

KW - Dna repair

KW - Embryonic stem cells

KW - Gene regulatory networks

KW - Induced pluripotent stem cells

KW - Oct4

KW - Proteomics

KW - Reprogramming

KW - Self-renewal

KW - Sox2

KW - Transcription factors

KW - Transcriptional circuitry

UR - http://www.scopus.com/inward/record.url?scp=84877102425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877102425&partnerID=8YFLogxK

U2 - 10.1002/stem.1352

DO - 10.1002/stem.1352

M3 - Short survey

C2 - 23401375

AN - SCOPUS:84877102425

VL - 31

SP - 1033

EP - 1039

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 6

ER -